![免疫应答概论_第1页](http://file4.renrendoc.com/view/4ac27ae6b9ac3b4dffd26de1a67ff6dc/4ac27ae6b9ac3b4dffd26de1a67ff6dc1.gif)
![免疫应答概论_第2页](http://file4.renrendoc.com/view/4ac27ae6b9ac3b4dffd26de1a67ff6dc/4ac27ae6b9ac3b4dffd26de1a67ff6dc2.gif)
![免疫应答概论_第3页](http://file4.renrendoc.com/view/4ac27ae6b9ac3b4dffd26de1a67ff6dc/4ac27ae6b9ac3b4dffd26de1a67ff6dc3.gif)
![免疫应答概论_第4页](http://file4.renrendoc.com/view/4ac27ae6b9ac3b4dffd26de1a67ff6dc/4ac27ae6b9ac3b4dffd26de1a67ff6dc4.gif)
![免疫应答概论_第5页](http://file4.renrendoc.com/view/4ac27ae6b9ac3b4dffd26de1a67ff6dc/4ac27ae6b9ac3b4dffd26de1a67ff6dc5.gif)
版权说明:本文档由用户提供并上传,收益归属内容提供方,若内容存在侵权,请进行举报或认领
文档简介
免疫应答概论2lightchains(or)2heavychains(5isotypes:IgG,M,A,D,E)2Bindingsites(Divalent)SecretedintocirculationBindsSolubleAntigen2Chains/(95%)or/(5%)1Bindingsite(Monovalent)MembraneBound,NotSecretedBindsAntigenComplexedwithMHCZap70fynlckgezVVCCCH1CH2CH3CH2CH3CH1CLCLVLVLVHVHedzIga/IgbIga/IgbBlk,FynorLynBandTLymphocyteAntigenReceptorsBDC2021/4/272XPID:X-linkedpolyendocrinopathy,immunedysfunctionanddiarrheaXLAAD:“AutoimmunityAllergicDysreg”Scurfingene(Foxp3/JM2)Immunopathogenesis:Th2Cytokines,abnormalactivation(Il-4,5,13)
-Scurfy+Nude:NoAutoimmunity
-CD4+intoNude:Disease
-BoneMarrowintoirradiated:NoDisease
-RequireAntigenStimulationforDisease
-MixedChimera:NoDiseaseBDC2021/4/273HumanLeukocyteAntigenhumanMHCcell-surfaceproteinsimportantinselfvs.nonselfdistinctionpresentpeptideantigenstoTcellsCLASSI:A,B,CCLASSII:DR,DQ,DPHLAJ.Noble2021/4/274TheHumanLeukocyteAntigenComplex(6p21.31)DPDQDRBCAClassII
(1.1Mb)ClassIIIClassI(2.2Mb)ComplementandCytokinesClassI-likegenesandpseudogenesFrequentRecombinationRecombinationisRareTelomereCentromereRecombinationisRare(0.7Mb)BDC2021/4/275a3b2a1a2a1a2b1b2Binds8-10mersExpressedonmostNucleatedcellsPresentsCytosolicProteinstoCD8+TcellsBinds13-25mersExpressedonAPCs,Macs,Bcells,activatedTcellsPresentsVesicularProteinstoCD4+TcellsClassI ClassIIHLAClassIandIIMoleculesHaveaDistinctStructureandFunctionBDC2021/4/2760501
020103010302ciscisDQA1 DQB1transDQA1*0301/DQB1*0201DQA1*0501/DQB1*0302DQA1*0501/DQB1*0201DQA1*0301/DQB1*0302MaternalPaternalCisandTrans-ClassIIDimerizationBDC2021/4/277DQB1*0402Asp57Leu56-chain-chainBDCBDC2021/4/278HLA-Peptide:TCRCDR1CDR2CDR3CDR3CDR2CDR1NH3+COO-TCRalphaTCRbeta2Helixα1HelixBDC2021/4/279Co-Stimulation
TCellAPCCTLA-4-CD28+CD154(CD40L)CD2CD58CD40B7(+)IL-1,IL-6,TNFIL-10TGF(-)TCR-MHCBDC2021/4/2710AbsenceofSignal2ActivationClonalAnergyorDeletionTCRMHCAPCToleranceTCellTCRMHCAPCSignal1+Signal2B7TCellcytokinesCD28The2-SignalModelofLymphocyteActivationBDC2021/4/2711MHC/self-peptideCD4MHC/VbCD4CD4+VbxTcell
APCActivatedautoreactiveCD4+TCRVbxTH1cell
TCRVbxTCRVbx(1)expansionofCD4+,autoreactiveTH1cellsspecificforautoantigens(2)migrationandinfiltrationoftheseselfreactiveCD4+TH1cellsintotissuesandinductionofinflammationandautoimmunity(3)inductionofregulatorycellswhichcontrolthegrowthandactivationofthepathogenicautoreactiverepertoireofCD4+TcellsInductionofCD4+TH1mediatedautoimmunity:Aparadigmforthepathogenesisofrheumatoidarthritis,multiplesclerosisandtypeIdiabetesL.Chess20022021/4/2712TH1CD4+cellsTH2CD4+cellsCD8orCD4suppressorprecursorCD8orCD4suppressoreffectorActivatedCD4Tcellspeptide/APC
RegulatoryimmunityCD4/CD8interactions(-)(-)TheControlofActivatedCD4+TCellsbyRegulatoryTcellsApoptosisRestingCD4TcellsIL-12/IFN-gIL-4NKTcells/CD4+CD25+cellsCD4+CD25-cells(-)(-)IL-10IFN-gL.Chess20022021/4/2713TcellactivationisregulatedbysignalsderivedfromtheTCR/CD3/CD4complexandtheCD40LandCD28/CTLA-4co-stimulatorymolecules
gedzzCD3MHCclassII
a,b
TCRhhPeptideantigenCD4+
TCell
AntigenPresentingCell(APC)VaVbCaCbCD4AntigenspecificTCRsignalsCD40CD40LsignalCD28/CTLA-4CD80(B7.1)/CD86(B7.2)lckCo-stimulatorysignals(-)/[+][+]L.Chess20022021/4/2714gedVaCaCbVbzzp56lck
peptideCD3CD28CD40LFA-3LFA-1ICAM-1MHCIIB7CD40LCD4CD45TCRCD2CD4+TCellAPC/BcellhhMolecularInteractionsofHelperTCellsandAPCB7CTLA-4VLA-1CollagenCD80/CD86L.Chess20022021/4/2715MHC/peptideTCRQa-1/VbActivatedCD4+TcellRestingCD4+TcellDown-regulationofActivatedCD4+TCellsTcellactivationinducesexpressionoffunctionalTcellsurfacemoleculesRegulatoryCD8+TcellTCR
(anti-Qa-1/Vb)
ActivatedCD8+Tcell(+)(-)TCRAPCTCRLateActivatedCD4+TcellVLA-1CollagenCD40LMigrationofsitesofinflammationInductionandactivationofBcellsAPCsCD25L.Chess20022021/4/2716ActivatedTH1CD4+TCellCD4+Cell(TH2)CD4+Cell(TH0)DR3,DR4,,DQ8/insulinpeptide
CD2Macrophage/dendriticcellFcR
IFN-g
IL-12CD40LCD40a,b,TCRIL-1,TNF,LT,NO,PGE-2BCell?anti-insulin,GADabanti-MogIL-4ImmunopathophysiologyofDiabetes?AntibodymediatedinjuryDendriticcell/APCCD40LIL-4CD40LCD8+CTLFasLperforinbcelldeathbisletcellsL.Chess20022021/4/2717InnateImmuneSystem:Toll-likereceptoractivationofAPC
TCellCD28B7TCR-MHCLPSTollLikeReceptor(patternRecognitionR)IL-1,6,12“Signal3”Signal2Signal1AnitgenPresentingCell(APC)BDC2021/4/2718Th1vs.Th2CD4TCellsTh1IL-12fordifferentiationCytokines:
Interferon-
Interleukin-2IntracellularPathogensCD8CytotoxicityDelayedTypeHypersensitivityMacrophageActivationTh2IL-4fordifferentiationCytokines:
Inerluekin-4
Inter
温馨提示
- 1. 本站所有资源如无特殊说明,都需要本地电脑安装OFFICE2007和PDF阅读器。图纸软件为CAD,CAXA,PROE,UG,SolidWorks等.压缩文件请下载最新的WinRAR软件解压。
- 2. 本站的文档不包含任何第三方提供的附件图纸等,如果需要附件,请联系上传者。文件的所有权益归上传用户所有。
- 3. 本站RAR压缩包中若带图纸,网页内容里面会有图纸预览,若没有图纸预览就没有图纸。
- 4. 未经权益所有人同意不得将文件中的内容挪作商业或盈利用途。
- 5. 人人文库网仅提供信息存储空间,仅对用户上传内容的表现方式做保护处理,对用户上传分享的文档内容本身不做任何修改或编辑,并不能对任何下载内容负责。
- 6. 下载文件中如有侵权或不适当内容,请与我们联系,我们立即纠正。
- 7. 本站不保证下载资源的准确性、安全性和完整性, 同时也不承担用户因使用这些下载资源对自己和他人造成任何形式的伤害或损失。
最新文档
- 《财务报表分析G》课件2
- 企业培训师复习试题附答案
- 《非均相物系分离》课件
- 高中物理项目化学习路径探究
- 《高空作业操作规范》课件
- 《专题数列》课件
- 绿色农业产业合作协议
- 九年级语文愚公移山课件教案
- 服装设计行业服装样品制作合同
- 11 白桦 第一课时 说课稿 -2023-2024学年语文四年级下册统编版
- 医疗器械销售目标分解
- 射线衍射原理
- 中华全国总工会办公厅印发《加快工会数字化建设工作方案》
- 中国通用电气有限公司员工手册
- 汽车电气设备构造与维修(高职版)全套教学课件
- 成人住院患者静脉血栓栓塞症预防护理
- 四年级数学(四则混合运算)计算题专项练习与答案汇编
- 国家基本公共卫生服务项目绩效考核课件
- 孕产妇深静脉血栓预防与护理课件
- 研发运营一体化DevOps能力成熟度模型评估(完整版)
- 《3-6岁儿童学习与发展指南》健康领域内容目标与指导
评论
0/150
提交评论