PMEDAP-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEPMEDAPCat.No.:HY-106382CASNo.:113852-41-8分⼦式:C₈H₁₃N₆O₄P分⼦量:288.2作⽤靶点:HIV;CMV作⽤通路:Anti-infection储存⽅式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性数据体外实验0.1MNaOH:14.29mg/mL(49.58mM;ultrasonicandadjustpHto12withNaOH)MassSolvent1mg5mg10mgConcentration制备储备液1mM3.4698mL17.3491mL34.6981mL5mM0.6940mL3.4698mL6.9396mL10mM0.3470mL1.7349mL3.4698mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性PMEDAP⼈类免疫缺陷病毒(HIV)复制的有效抑制剂。PMEDAP具有抗⼩⿏巨细胞病毒(MCMV)活性。PMEDAP罗尼⿏⾁瘤病毒(MSV)诱导的肿瘤形成和相关死亡率的有效抑制剂。体内研究PMEDAP(0.25-5mg/kg;IP;daily;startingonthedayofMSV-infectedandcontinuingforanadditionalfourdays)causesadose-dependentsuppressionoftumorformationandmortalityinnewbornmiceinoculatedwithMSV[1].1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEAnimalModel:Three-week-oldmaleNMRImice[1]Dosage:0.25mg/kg,1mg/kg,5mg/kgAdministration:IP;daily;startingonthedayofinfectionandcontinuingforanadditionalfourdaysResult:Effectedasignificantdelayintumorappearanceandanenhancementofthesurvivalrateoftumor-bearingmice.REFERENCES[1].NeytsJ,etal.Activityoftheanti-HIVagent9-(2-phosphonyl-methoxyethyl)-2,6-diaminopurineagainstcytomegalovirusinvitroandinvivo[publishedcorrectionappearsinEurJClinMicrobiolInfectDis1993Jul;12(7):following477].EurJClinMicrobiolInfectDis.1993;12(6):437-446.[2].NaesensL,etal.9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine(PMEDAP):anovelagentwithanti-humanimmunodeficiencyvirusactivityinvitroandpotentanti-Moloneymurinesarcomavirusactivityinvivo.EurJClinMicrobiolInfectDis.1989;8(12):1043-1047.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400