目前国际最新制剂发展动态及加工关键技术介绍-先正达课件

AgrochemicalFormulationTrends

农药制剂的发展趋势CCPIAGuilin,Guangxi,China中国–桂林KeithParker,Ph.D.SyngentaAsiaPacificPte.Ltd.AgrochemicalFormulationTrendWhoisSyngenta

先正达介绍AgrochemicalFormulationTrends

农业化学配方的发展趋势Contents内容WhoisSyngenta

先正达介绍ContentsOurindustryfamilytree国际农化公司发展概况CibaSandozICIISKBiosciencesMonsantoDuPontShellCyanamidBASFBayerRhone-PoulencHoechstScheringDowRohm&HaasMerck1992199319941995199619971998199920002001NovartisAHPAventis2002AgrevoZenecaOurindustryfamilytree国际农化公Excellentcomplementaryandleadingproductportfolio

卓越全面、领先的产品线Aleaderincropprotection植保领域的领先者Thirdinhigh-valuecommercialseeds高价值商业种子排名第三Firstclassresearchanddevelopmentresources一流的研发资源

Investmentofaround$800mannually

每年投入约八亿美元Strongworldwidepresence

业务遍布全球Around21,000employeesinover90countries在90多个国家拥有2万1千名雇员RichpipelineofCropProtectionandSeedsproducts

丰富的植保和种子产品产销渠道Syngenta–aleadingglobalagribusiness

先正达－全球领先的农业科技公司ExcellentcomplementaryandleSyngenta–aleadingglobalagribusiness

先正达－全球领先的农业科技公司

milliontonnesofcottonisgrownusingourcropprotectionproducts

全球440万吨棉花种植过程中使用先正达植保产品

That’stheequivalentof20billionT-Shirts

这相当于200亿件T恤的用料4.4Syngenta–aleadingglobalagSyngenta–aleadingglobalagribusiness

先正达－全球领先的农业科技公司70%

ofScotchWhiskyisproducedbySyngentabarley70%苏格兰威士忌是用先正达大麦制造的Syngenta–aleadingglobalagWhatWeDo

我们从事哪些业务CropProtection

作物保护Seeds

种子

ProfessionalProducts

专业产品

Bio-technology

生物技术

WhatWeDo我们从事哪些业务CropSeeds

Majorproductbrands主要的产品品牌Herbicides

除草剂Professionalproducts

专业产品Fungicides

杀菌剂Insecticides

杀虫剂Seeds

种子阿克泰金雷世高阿米西达锐胜泰草达克无踪功夫千层红Majorproductbrands主要的产品品牌HeRank

排名2006R&Dspend

2006

研发投入$m1 Syngenta先正达

2 Bayer拜尔4 BASF巴斯夫5

DuPont

杜邦3

Monsanto

孟山都6 Dow

陶氏As%ofSales

销售百分比％11%10%10%14%

11%10%Theleaderinresearchanddevelopment

先正达，研究与开发的领导者Source:PhillipsMcDougall,SyngentaRank

排名2006R&Dspend

2006研发投MajorR&Dsites

locatedatthe

heartofscientificcommunitiesOthersitesMarker-assistedandseedbreedingcapabilitiesGlobalfieldstationnetworkGlobalR&Dcapabilities全球研发机构美国格林斯博罗GREENSBOROFormulationEnvironmentalScience美国SBIBiotechnologyR&D英国集能山JEALOTT’SHILLChemicalDiscoveryWeedControlFormulationBioscienceEnvironmentalScience瑞士巴塞尔/斯坦恩BASEL/STEINFungicides,Insecticides&ProfessionalProducts印度果阿GOAChemistryMajorR&Dsites

locatedatthSyngentainChina先正达在中国CropProtection

作物保护Seeds

种子

ProfessionalProducts

专业产品R&D

研发SyngentainChina先正达在中国CropSAhistoryofmorethan100years

百多年合作历史AssociatedinvestmentUS$200m目前总投资达2亿美元

40%ofthetotaldirectforeigninvestmentinCPsection投资额占中国市场植保领域外商直接投资的40％InvestmentinChina

先正达在中国的投资Syngenta(Suzhou)CropProtectionCo.,Ltd.SyngentaSeeds

CompanyLtd.SyngentaNantongCropProtectionCo.,Ltd.Ahistoryofmorethan100yeaEnvironmentProtectionResponsibilityinChina

先正达在中国环保社会责任“Top100EnvironmentalFriendlyProjects”byStateEnvironmentalProtectionAdministration“—theonlyoneofitskindincropprotectionindustry“

国家环保局授予的“百佳环保工程”荣誉称号－植保行业中唯一获此殊荣

“Top10environmentalfriendlyenterprises”“江苏省十大环保企业”

“High-techenterprises”inJiangsuprovince”“江苏省高新技术企业”

Providetechnicalsupportforindustry/nationalstandardssetup

为行业标准设定提供技术支持

EnvironmentProtectionResponsChina’ssustainableagriculturedevelopmentthroughinnovativeresearchandtechnology

通过创新性的研究和技术，中国农业的可持续性发展Improvecropproductivity,qualityandsafetythroughintegratedsolutions

通过完整的方案，提高和改善作物产量，质量和安全性UpgradeChinesefarmer’sincomeandthequalityoflife

提升中国农民的收入和生活质量SyngentaChinaisCommittedTo

先正达中国忠于..China’ssustainableagriculturWhoisSyngenta

先正达介绍AgrochemicalFormulationTrends

农业化学配方的发展趋势Contents内容WhoisSyngenta

先正达介绍ContentsFormulationTechnology制剂技术AgribusinessinvestsheavilyinFormulationScience

在制剂技术的上开发上，农化企业投入重金BothforfirstlaunchofnewActiveIngredientsandproductlife-cyclemanagement对新开发的原药及老的原药在制剂技术上都会投入重金Why?

为什么？FormulationTechnology制剂技术AgrWhyFormulation?为什么要制成制剂使用？ActiveIngredientsdon’twork….

原药本身没有药效…………..Untiltheyaremadeintoformulations

……除非原药被做成制剂后使用

Ourcustomersbuyformulatedproductsinpacks我们的客户购买的是包装好的农药制剂产品Solutions溶液Emulsions乳液Suspensions悬浮液Solids固体Capsules胶囊WhyFormulation?为什么要制成制剂使用？AcUntreated没有使用过农药Untreated没有使用过农药Un-FormulatedHerbicide

未经制剂加工的除草剂Un-FormulatedHerbicide未经制剂加工FormulatedHerbicide

经过配制的除草剂FormulatedHerbicide经过配制的除草剂LiquidFormulationSCSL,EC

液体制剂－水悬浮剂、可溶性液剂、乳油ConcentratedFlowable具流动性的浓缩产品Ondilution稀释过程(SC:suspensionconcentrate;SL:solubleconcentrate;EC:Emulsifiableconcentrate

LiquidFormulationSCSL,EC

液SolidFormulationsWPWG固体制剂－可湿粉、水分散粒剂WP:WettablePowder可湿性粉剂WG水分散粒剂

WG(Pepite)WPWG:WaterDispersibleGranule水分散粒剂

可湿性粉剂SolidFormulationsWPWG固体制剂RequirementsofaFormulation制剂产品的要求Basicrequirements基本要求Easy&safetohandle操作简单和安全Canbeapplied(sprayed,etc)方便使用（如喷洒等）Worksbiologically具有生物活性Stable(physicallyandchemically)稳定性（物理、化学稳定性）Canbemanufactured(tocost)合适的生产成本Addedvaluefromformulations

配成制剂的增值作用Attractiveandeasytohandle能吸引人并容易操作Improvedsafety提高其安全性Improvedefficacy提高其药效RequirementsofaFormulationWettablepowder可湿性粉剂applicationinEgyptcirca1980应用在埃及大约在1980Wettablepowder可湿性粉剂Agriculturalformulationscanbeverysophisticated

农药制剂具有悠久的历史triggerrupturesweaklinkforfastreleaseatrightplace/timeTriggeredrelease触发释放Polymerlayers聚合物层Firstgeneration第一代Newsurfaceproperties新表面特性Anionic阴离子Cationic阳离子Liquid液体+-Improvedhandling改善操作Targetedactivity活性目标Differentiatedproducts

产品多样化Newmarkets

新市场Extended

patentprotection

扩大专利保护范围ZeonisaReg.trademark触发剂割裂脆弱处在合适的时间/地点释放AgriculturalformulationscanCropProtectionIndustry:aviewfromtheWest

西方作物保护工业概览Approx$30Billionperannumsales每年销售额大约300亿美元Marketdrivers市场驱动Performanceenhancement增强药效CostReduction降低成本Environment/regulations环境/法规Environmentalconcerns环境关注Fewernewactives/newmodesofaction新原药较少/新作用模式Lifecyclemanagement产品的生命周期管理Howtoenhancevalueofmatureactiveingredients?

怎样增加成熟原药的价值？CropProtectionIndustry:aviWhatdoCompaniesthink?公司在考虑什么？

“Productinnovationusingexistingactiveingredients”

“运用新技术对现有的原药进行创新”

Combiningactiveingredientsinnovelcombinationproductsdrivesinnovation.运用新技术，对产品重新配制，以推动创新。Novelformulationtechnologyenablesnewproductsfromexistingcompoundswhichhavenewlevelsofactivity,safetyandspectrum,bothassprayedproductsandincreasinglyasseedtreatments.

利用新的制剂技术可以使现有的原药，无论是用于喷洒还是日益增长的种子处理剂，成为高效、安全、广谱的新产品。Bayerannualreview:拜尔年度回顾Formulationknow-howtranslatesintocompetitiveedge制剂技术成为竞争的优势Differenttechnologiesareusedtoformulatetheactiveingredientintoaproductwithoptimalapplicationproperties采用的不同技术，将原药配制成具有最佳应用性能的产品SyngentaAnnualReview2005先正达2005年度回顾WhatdoCompaniesthink?公司在考虑FormulationTrends制剂的发展趋势

Increasingcomplexity日益复杂mixtures,AIproperties,noveltechnology,混合制剂，原药的性能，新型技术Continuedregulatorypressure(environment)

持续的法规压力（环境）costpressures成本压力Formulationdifferentiationincreasinglyimportanttoagribusiness制剂的多样性对农业行业日益重要FormulationTrends制剂的发展趋势IncFormulationResearch:HistoricView

制剂技术研究：历史回顾1970’s2000’s1990’s1980’sEC’sandWPs乳油和可湿性粉剂SC’sandEW’s水悬浮剂&乳液o/wMicrocapsules微胶囊WGs水分散颗粒Adjuvants助剂NovelPhysicalForms具有新性能的产品OilDispersions油分散产品Safety安全Safety,EnvironmentalandEfficacy安全，环境和有效Convenience/Safety/Environmental方便/安全/环境Efficacy有效Convenience方便Convenience/labileAIs方便/有效成份进入植物组织FormulationResearch:HistoriFormulationBenefits配制成制剂的益处Casestudies:

实例研究Increasedbiologicalperformance(adjuvants)增强生物性能（助剂）Improvedhandlingandapplicationcharacteristics

改善操作和应用特性Controlledrelease&enhancedsafety

控制释放和增强安全性FormulationBenefits配制成制剂的益处CIncreasedbiologicalperformance

增强生物活性Theuseofadjuvantsmayimprovetheperformanceorallowareducedrateofmanyactiveingredients

助剂的使用可以改善应用性能或可以降低使用原药的用量IncreasedbiologicalperformanAdjuvants:ImprovedEfficacy助剂：改善功效Example:Adjuvantcanimproveactivityby:increasingdropletspreadincreasingleafuptake例如：助剂可以通过下列方式改善活性增加液滴的扩散增加植物叶片的吸收Noadjuvant

没有助剂Withadjuvant

有助剂Noveladjuvant新型助剂‘Standard’adjuvant标准助剂Noadjuvant无助剂时间Adjuvants:ImprovedEfficacy助Adjuvancy:the“on-off“switchforpinoxaden

当天应用未处理没有助剂有助剂未处理没有助剂有助剂应用20天以后Adjuvancy:the“on-off“switchNotJustHerbicides!不只是除草剂

BayerWOO2098230-fattyalcoholalkoxylateswithinsecticides

拜尔WOO2098230－烷氧基脂肪醇与杀虫剂

WO2003/099012A1Syngenta先正达2003/09912A1

Useofphosphonateadjuvantswithinsecticides在杀虫剂中使用磷酸酯做助剂Exemplifiedbybis(2-ethylhexyl)-2-ethylhexylphosphonate(BEEP)例如：双（2－乙基己基）－2－乙基己基磷酸酯％吸收/转移24小时后吸收/转移48小时后吸收/转移死亡率％多杀菌素氯芬新

甲氨基阿维菌素苯甲酸盐死亡率％死亡率％吸收/imidacloprid的转移NotJustHerbicides!不只是除草剂BaImprovedHandlingandApplication

改善操作和应用FormulaM,anewtechnologyinSeedTreatment配方M，在种子处理中的新技术ImprovedHandlingandApplicatTreatedseeds种子处理CelestExtra(current)CelestExtra（目前）CelestExtraFormulaMCelestExtra配方MFormulaMprovides配方M可以具有Improvedcoverage(homogeneityoftreatment)改善覆盖层（处理均匀性）Improvedappearance(strongercolour)改善外观（较强的色泽）

Reducedhumanexposure(lessdust-off)减少与人体接触（较少脱落）Fasterprocessingoftreatedseed(fasterdrying)加快种子处理过程（快速干燥）Treatedseeds种子处理CelestExtraLessDust-off:saferproduct

更少的脱落：更安全的产品Dust-offfilter,A8533F@200mL/100kgonwheat,dilutedwith400mLwaterST22TA828/03粉尘滤膜，A8533F@200ml/100kg，用于小麦。用400ml水稀释ST22TA828/03Dust-offfilter,A8533G@200mL/100kgonwheat,dilutedwith400mLwaterST22TA828/09

滤膜A8533G@200mL/100kg，用于小麦。用400ml水稀释ST22TA828/09CelestExtra(current)目前CelestExtraFormulaM配方M脱落，克/100公斤小麦LessDust-off:saferproductHigherproductivityfortreatingcompanies

种子处理公司有更高的生产能力Celest025FS(current)目前Celest025FSformulaM配方MImprovementofbaggingtimeby15%!减少15％的包装时间HigherproductivityfortreatiControlledReleaseandEnhancedSafety控制释放和增强安全性KarateandDemand:microencapsulationprovidesmanybenefits功夫和大灭：微胶囊化可以提供很多好处ControlledReleaseandEnhanceMicroencapsulation

(1stGeneration)微胶囊化（第一代）polymericWall聚合物壁Water水Lambda

in

solvent高效氯氟氰菊脂在溶剂中UVprotectant

紫外线保护剂DemandHighloadcapacity;safening;environmental高容量；安全；环保Robust-designedforslowrelease

可靠-设计为缓慢释放Microencapsulation(1stGeneraMicro-encapsulation(2ndGeneration)微乳胶囊化（第二代）氯氟氰菊酯微胶囊剂

Improvedsafety改善安全性Safermammaliantox对哺乳动物更安全Lowersolventlevels更低的溶剂量Improvedperformance改善性能Efficacy>ECbyfastrelease功效>通过快速释放的ECUVprotectant防紫外线保护剂LambdaDemandParathion-methylLambdaZeonMicro-encapsulation(2ndGenerCapsuleSuspensions悬浮剂Capsulessuspendedinaliquidbasegivingaflowablesuspensionconcentrate.

胶囊悬浮在液体中，生产出具有流动性的悬浮剂CapsuleSuspensions悬浮剂CapsuMicrocapsules微胶囊Typically1-20micronhollowspheresfilledwithAI通常活性成分被填入1～20微米的空心球中Highloadcapacity高容量Aqueous(CS)ordryproducts水溶液（悬浮液）或固体产品Reservoir储存囊Matrix母体Microcapsules微胶囊Typically1-Controlofparameterstovaryreleaserate:控制参数以控制释放速率：particlesize颗粒大小monomercomposition单体成分cross-linkdensity铰链密度wallthickness壁厚Stabiliser稳定剂polymeric

wall聚合物墙壁continuousPhase连续相

ActiveIngredient活性成分r’r”c'c"ConventionalMicrocapsulesReleasebyDiffusionControl

常规的微胶囊释放是由控制扩散完成的释放速率表面积扩散浓度墙壁厚度渗透性扩撒系数分配系数ControlofparameterstovaryApplicationsBeyondConventionalTechnology

新技术的应用Reducedmammaliantox降低哺乳动物毒性TargetingagainstpestPressure将害虫作为目标的压力seasonlongcontrolfromoneapplication一次施药可长期有效Reducedantagonism降低抗性Hours/days/monthsTriggers;触发剂pH,light,temp，pH，光线，温度

Hours/days/monthsAIseenbytarget农药有效成份到达标靶EC浮油Microcap微胶囊Hrs/days/mthsExtendedreleaseforestablishedbenefits延长有效成份释放到受药体researchchallenges!研究挑战Beneficialinsectprotection保护益虫ApplicationsBeyondConventionChemicallyTriggeredReleaseStrategy

化学方法触发法customdesignedweaklinksareincorporatedintothewallduringpolymerisation在聚合过程中将结合力较弱的物质嵌入内壁triggerisactivatedatchosenmoment-rupturesweaklink在合适的时间，触发剂被激活，结合力较弱处断裂puncturesreducewallthickness(r’-r”)tozero,circumventingthenormaldiffusionprocess

渗透物使壁厚变小(r’-r”)到0，打破常规的正常的扩散过程triggerrupturesweaklinkallowingfastreleaseweaklinkAIAI触发剂可以快速释放结合力较弱处裂开释放率结合力较弱的物质ChemicallyTriggeredReleaseSAcidTriggeredCapsules酸触发胶囊Non-triggered没有被触发的Triggered触发的AcidTriggeredCapsules酸触发胶囊NoFutureVision:FromaWesternperspective

未来前景：西方展望Furtherrestrictionsintheregulatoryenvironment

环境法规更加严格Continuedneedforsafer,moreeffectiveproducts持续需要更安全，更有效的产品Increasedaccessibilitytousefultriggeredsystemsfortargeteddelivery

利用有用的触发机制，增强（药物）达到目标受体能力Improvedadjuvantsofferreducedapplicationrates改善助剂以降低施用量Increasedroleofpolymericsystemstodeliverbettercontrolledreleasesystems(includingnanotechnologies)

增加聚合系统的作用，更好地控制释放系统（包括纳米技术，10-9）Greaterunderstandingofcrystallisationprocesses更好地了解结晶过程Changingpesticidechemistrieswillprovidecontinuallychangingchallengestotheformulator不断变化的农药化学将会对制剂开发人员带来持续的挑战FutureVision:FromaWesternFormulationResearch:Future制剂研究：未来1990’s???2010’s2000’sNewEC’sandsolvents新型乳油及溶剂SC’sandEW’s-morerobusttechnology悬浮剂和乳液－更多的完备技术Controlleddelivery控制传递Newdryproductstechnology新型固体制剂技术Adjuvantsanduptakeunderstanding辅剂和吸收的认识NovelPhysicalForms

改变物理性能新技术Newdeliverytechnology新型传递技术FormulationResearch:FutureFormulationFailure?

配方会失败？Riskfactors:风险因素-Developmentwastoofast

发展太快-Poorrawmaterials

原料贫乏-Nottestedinproperconditions

未在合适的条件进行测试Impactoffailure:

失败带来的影响-Poorhandling(sediment,blockedscreens)

施用困难（沉淀，堵塞）-Cropinjury(toomuchproductapplied)伤害作物（用药量太大）-Lackofefficacy(notenoughproductapplied)

缺乏药效（产品的应用不充分）-Humanexposure(cleaningupthemess!)人体暴露（处理废物）-Reducedcropyield(impropertreatment)

降低作物产量（不恰当的使用）FormulationFailure?配方会失败？RisConclusions

结论Formulationsprovidemanybenefits

制剂可以再来很多好处Improvedefficacy

改善药效Improvedapplication

改善应用Saferhandling

更安全的操作Improvedenvironmentalprofile

改善环境Etc.

等等Properformulationdevelopmentcantakeyearsofresearchinthelaboratory

一个合适的制剂通常需要在实验室里经过数年的研究Doitright!Reducetheriskoffailure

正确的方法可以降低失败的风险Addedbenefits&developmenttimecostsmoney!

增加产品的价值及花费的研发时间是需要投资的！Conclusions结论FormulationsprTHANKYOU!谢谢THANKYOU!AgrochemicalFormulationTrends

农药制剂的发展趋势CCPIAGuilin,Guangxi,China中国–桂林KeithParker,Ph.D.SyngentaAsiaPacificPte.Ltd.AgrochemicalFormulationTrendWhoisSyngenta

先正达介绍AgrochemicalFormulationTrends

农业化学配方的发展趋势Contents内容WhoisSyngenta

先正达介绍ContentsOurindustryfamilytree国际农化公司发展概况CibaSandozICIISKBiosciencesMonsantoDuPontShellCyanamidBASFBayerRhone-PoulencHoechstScheringDowRohm&HaasMerck1992199319941995199619971998199920002001NovartisAHPAventis2002AgrevoZenecaOurindustryfamilytree国际农化公Excellentcomplementaryandleadingproductportfolio

卓越全面、领先的产品线Aleaderincropprotection植保领域的领先者Thirdinhigh-valuecommercialseeds高价值商业种子排名第三Firstclassresearchanddevelopmentresources一流的研发资源

Investmentofaround$800mannually

每年投入约八亿美元Strongworldwidepresence

业务遍布全球Around21,000employeesinover90countries在90多个国家拥有2万1千名雇员RichpipelineofCropProtectionandSeedsproducts

丰富的植保和种子产品产销渠道Syngenta–aleadingglobalagribusiness

先正达－全球领先的农业科技公司ExcellentcomplementaryandleSyngenta–aleadingglobalagribusiness

先正达－全球领先的农业科技公司

milliontonnesofcottonisgrownusingourcropprotectionproducts

全球440万吨棉花种植过程中使用先正达植保产品

That’stheequivalentof20billionT-Shirts

这相当于200亿件T恤的用料4.4Syngenta–aleadingglobalagSyngenta–aleadingglobalagribusiness

先正达－全球领先的农业科技公司70%

ofScotchWhiskyisproducedbySyngentabarley70%苏格兰威士忌是用先正达大麦制造的Syngenta–aleadingglobalagWhatWeDo

我们从事哪些业务CropProtection

作物保护Seeds

种子

ProfessionalProducts

专业产品

Bio-technology

生物技术

WhatWeDo我们从事哪些业务CropSeeds

Majorproductbrands主要的产品品牌Herbicides

除草剂Professionalproducts

专业产品Fungicides

杀菌剂Insecticides

杀虫剂Seeds

种子阿克泰金雷世高阿米西达锐胜泰草达克无踪功夫千层红Majorproductbrands主要的产品品牌HeRank

排名2006R&Dspend

2006

研发投入$m1 Syngenta先正达

2 Bayer拜尔4 BASF巴斯夫5

DuPont

杜邦3

Monsanto

孟山都6 Dow

陶氏As%ofSales

销售百分比％11%10%10%14%

11%10%Theleaderinresearchanddevelopment

先正达，研究与开发的领导者Source:PhillipsMcDougall,SyngentaRank

排名2006R&Dspend

2006研发投MajorR&Dsites

locatedatthe

heartofscientificcommunitiesOthersitesMarker-assistedandseedbreedingcapabilitiesGlobalfieldstationnetworkGlobalR&Dcapabilities全球研发机构美国格林斯博罗GREENSBOROFormulationEnvironmentalScience美国SBIBiotechnologyR&D英国集能山JEALOTT’SHILLChemicalDiscoveryWeedControlFormulationBioscienceEnvironmentalScience瑞士巴塞尔/斯坦恩BASEL/STEINFungicides,Insecticides&ProfessionalProducts印度果阿GOAChemistryMajorR&Dsites

locatedatthSyngentainChina先正达在中国CropProtection

作物保护Seeds

种子

ProfessionalProducts

专业产品R&D

研发SyngentainChina先正达在中国CropSAhistoryofmorethan100years

百多年合作历史AssociatedinvestmentUS$200m目前总投资达2亿美元

40%ofthetotaldirectforeigninvestmentinCPsection投资额占中国市场植保领域外商直接投资的40％InvestmentinChina

先正达在中国的投资Syngenta(Suzhou)CropProtectionCo.,Ltd.SyngentaSeeds

CompanyLtd.SyngentaNantongCropProtectionCo.,Ltd.Ahistoryofmorethan100yeaEnvironmentProtectionResponsibilityinChina

先正达在中国环保社会责任“Top100EnvironmentalFriendlyProjects”byStateEnvironmentalProtectionAdministration“—theonlyoneofitskindincropprotectionindustry“

国家环保局授予的“百佳环保工程”荣誉称号－植保行业中唯一获此殊荣

“Top10environmentalfriendlyenterprises”“江苏省十大环保企业”

“High-techenterprises”inJiangsuprovince”“江苏省高新技术企业”

Providetechnicalsupportforindustry/nationalstandardssetup

为行业标准设定提供技术支持

EnvironmentProtectionResponsChina’ssustainableagriculturedevelopmentthroughinnovativeresearchandtechnology

通过创新性的研究和技术，中国农业的可持续性发展Improvecropproductivity,qualityandsafetythroughintegratedsolutions

通过完整的方案，提高和改善作物产量，质量和安全性UpgradeChinesefarmer’sincomeandthequalityoflife

提升中国农民的收入和生活质量SyngentaChinaisCommittedTo

先正达中国忠于..China’ssustainableagriculturWhoisSyngenta

先正达介绍AgrochemicalFormulationTrends

农业化学配方的发展趋势Contents内容WhoisSyngenta

先正达介绍ContentsFormulationTechnology制剂技术AgribusinessinvestsheavilyinFormulationScience

在制剂技术的上开发上，农化企业投入重金BothforfirstlaunchofnewActiveIngredientsandproductlife-cyclemanagement对新开发的原药及老的原药在制剂技术上都会投入重金Why?

为什么？FormulationTechnology制剂技术AgrWhyFormulation?为什么要制成制剂使用？ActiveIngredientsdon’twork….

原药本身没有药效…………..Untiltheyaremadeintoformulations

……除非原药被做成制剂后使用

Ourcustomersbuyformulatedproductsinpacks我们的客户购买的是包装好的农药制剂产品Solutions溶液Emulsions乳液Suspensions悬浮液Solids固体Capsules胶囊WhyFormulation?为什么要制成制剂使用？AcUntreated没有使用过农药Untreated没有使用过农药Un-FormulatedHerbicide

未经制剂加工的除草剂Un-FormulatedHerbicide未经制剂加工FormulatedHerbicide

经过配制的除草剂FormulatedHerbicide经过配制的除草剂LiquidFormulationSCSL,EC

液体制剂－水悬浮剂、可溶性液剂、乳油ConcentratedFlowable具流动性的浓缩产品Ondilution稀释过程(SC:suspensionconcentrate;SL:solubleconcentrate;EC:Emulsifiableconcentrate

LiquidFormulationSCSL,EC

液SolidFormulationsWPWG固体制剂－可湿粉、水分散粒剂WP:WettablePowder可湿性粉剂WG水分散粒剂

WG(Pepite)WPWG:WaterDispersibleGranule水分散粒剂

可湿性粉剂SolidFormulationsWPWG固体制剂RequirementsofaFormulation制剂产品的要求Basicrequirements基本要求Easy&safetohandle操作简单和安全Canbeapplied(sprayed,etc)方便使用（如喷洒等）Worksbiologically具有生物活性Stable(physicallyandchemically)稳定性（物理、化学稳定性）Canbemanufactured(tocost)合适的生产成本Addedvaluefromformulations

配成制剂的增值作用Attractiveandeasytohandle能吸引人并容易操作Improvedsafety提高其安全性Improvedefficacy提高其药效RequirementsofaFormulationWettablepowder可湿性粉剂applicationinEgyptcirca1980应用在埃及大约在1980Wettablepowder可湿性粉剂Agriculturalformulationscanbeverysophisticated

农药制剂具有悠久的历史triggerrupturesweaklinkforfastreleaseatrightplace/timeTriggeredrelease触发释放Polymerlayers聚合物层Firstgeneration第一代Newsurfaceproperties新表面特性Anionic阴离子Cationic阳离子Liquid液体+-Improvedhandling改善操作Targetedactivity活性目标Differentiatedproducts

产品多样化Newmarkets

新市场Extended

patentprotection

扩大专利保护范围ZeonisaReg.trademark触发剂割裂脆弱处在合适的时间/地点释放AgriculturalformulationscanCropProtectionIndustry:aviewfromtheWest

西方作物保护工业概览Approx$30Billionperannumsales每年销售额大约300亿美元Marketdrivers市场驱动Performanceenhancement增强药效CostReduction降低成本Environment/regulations环境/法规Environmentalconcerns环境关注Fewernewactives/newmodesofaction新原药较少/新作用模式Lifecyclemanagement产品的生命周期管理Howtoenhancevalueofmatureactiveingredients?

怎样增加成熟原药的价值？CropProtectionIndustry:aviWhatdoCompaniesthink?公司在考虑什么？

“Productinnovationusingexistingactiveingredients”

“运用新技术对现有的原药进行创新”

Combiningactiveingredientsinnovelcombinationproductsdrivesinnovation.运用新技术，对产品重新配制，以推动创新。Novelformulationtechnologyenablesnewproductsfromexistingcompoundswhichhavenewlevelsofactivity,safetyandspectrum,bothassprayedproductsandincreasinglyasseedtreatments.

利用新的制剂技术可以使现有的原药，无论是用于喷洒还是日益增长的种子处理剂，成为高效、安全、广谱的新产品。Bayerannualreview:拜尔年度回顾Formulationknow-howtranslatesintocompetitiveedge制剂技术成为竞争的优势Differenttechnologiesareusedtoformulatetheactiveingredientintoaproductwithoptimalapplicationproperties采用的不同技术，将原药配制成具有最佳应用性能的产品SyngentaAnnualReview2005先正达2005年度回顾WhatdoCompaniesthink?公司在考虑FormulationTrends制剂的发展趋势

Increasingcomplexity日益复杂mixtures,AIproperties,noveltechnology,混合制剂，原药的性能，新型技术Continuedregulatorypressure(environment)

持续的法规压力（环境）costpressures成本压力Formulationdifferentiationincreasinglyimportanttoagribusiness制剂的多样性对农业行业日益重要FormulationTrends制剂的发展趋势IncFormulationResearch:HistoricView

制剂技术研究：历史回顾1970’s2000’s1990’s1980’sEC’sandWPs乳油和可湿性粉剂SC’sandEW’s水悬浮剂&乳液o/wMicrocapsules微胶囊WGs水分散颗粒Adjuvants助剂NovelPhysicalForms具有新性能的产品OilDispersions油分散产品Safety安全Safety,EnvironmentalandEfficacy安全，环境和有效Convenience/Safety/Environmental方便/安全/环境Efficacy有效Convenience方便Convenience/labileAIs方便/有效成份进入植物组织FormulationResearch:HistoriFormulationBenefits配制成制剂的益处Casestudies:

实例研究Increasedbiologicalperformance(adjuvants)增强生物性能（助剂）Improvedhandlingandapplicationcharacteristics

改善操作和应用特性Controlledrelease&enhancedsafety

控制释放和增强安全性FormulationBenefits配制成制剂的益处CIncreasedbiologicalperformance

增强生物活性Theuseofadjuvantsmayimprovetheperformanceorallowareducedrateofmanyactiveingredients

助剂的使用可以改善应用性能或可以降低使用原药的用量IncreasedbiologicalperformanAdjuvants:ImprovedEfficacy助剂：改善功效Example:Adjuvantcanimproveactivityby:increasingdropletspreadincreasingleafuptake例如：助剂可以通过下列方式改善活性增加液滴的扩散增加植物叶片的吸收Noadjuvant

没有助剂Withadjuvant

有助剂Noveladjuvant新型助剂‘Standard’adjuvant标准助剂Noadjuvant无助剂时间Adjuvants:ImprovedEfficacy助Adjuvancy:the“on-off“switchforpinoxaden

当天应用未处理没有助剂有助剂未处理没有助剂有助剂应用20天以后Adjuvancy:the“on-off“switchNotJustHerbicides!不只是除草剂

BayerWOO2098230-fattyalcoholalkoxylateswithinsecticides

拜尔WOO2098230－烷氧基脂肪醇与杀虫剂

WO2003/099012A1Syngenta先正达2003/09912A1

Useofphosphonateadjuvantswithinsecticides在杀虫剂中使用磷酸酯做助剂Exemplifiedbybis(2-ethylhexyl)-2-ethylhexylphosphonate(BEEP)例如：双（2－乙基己基）－2－乙基己基磷酸酯％吸收/转移24小时后吸收/转移48小时后吸收/转移死亡率％多杀菌素氯芬新

甲氨基阿维菌素苯甲酸盐死亡率％死亡率％吸收/imidacloprid的转移NotJustHerbicides!不只是除草剂BaImprovedHandlingandApplication

改善操作和应用FormulaM,anewtechnologyinSeedTreatment配方M，在种子处理中的新技术ImprovedHandlingandApplicatTreatedseeds种子处理CelestExtra(current)CelestExtra（目前）CelestExtraFormulaMCelestExtra配方MFormulaMprovides配方M可以具有Improvedcoverage(homogeneityoftreatment)改善覆盖层（处理均匀性）Improvedappearance(strongercolour)改善外观（较强的色泽）

Reducedhumanexposure(lessdust-off)减少与人体接触（较少脱落）Fasterprocessingoftreatedseed(fasterdrying)加快种子处理过程（快速干燥）Treatedseeds种子处理CelestExtraLessDust-off:saferproduct

更少的脱落：更安全的产品Dust-offfilter,A8533F@200mL/100kgonwheat,dilutedwith400mLwaterST22TA828/03粉尘滤膜，A8533F@200ml/100kg，用于小麦。用400ml水稀释ST22TA828/03Dust-offfilter,A8533G@200mL/100kgonwheat,dilutedwith400mLwaterST22TA828/09

滤膜A8533G@200mL/100kg，用于小麦。用400ml水稀释ST22TA828/09CelestExtra(current)目前CelestExtraFormulaM配方M脱落，克/100公斤小麦LessDust-off:saferproductHigherproductivityfortreatingcompanies

种子处理公司有更高的生产能力Celest025FS(current)目前Celest025FSformulaM配方MImprovementofbaggingtimeby15%!减少15％的包装时间HigherproductivityfortreatiControlledReleaseandEnhancedSafety控制释放和增强安全性KarateandDemand:microencapsulationprovidesmanybenefits功夫和大灭：微胶囊化可以提供很多好处ControlledReleaseandEnhanceMicroencapsulation

(1stGeneration)微胶囊化（第一代）polymericWall聚合物壁Water水Lambda

in

solvent高效氯氟氰菊脂在溶剂中UVprotectant

紫外线保护剂DemandHighloadcapacity;safening;environmental高容量；安全；环保Robust-designedforslowrelease

可靠