Cyclopentolate-hydrochloride-DL-Cyclopentolate-hydrochloride-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemECyclopentolatehydrochlorideCat.No.:HY-B1621ACASNo.:5870-29-1Synonyms:DL-Cyclopentolatehydrochloride分⼦式:C₁₇H₂₆ClNO₃分⼦量:327.85作⽤靶点:mAChR作⽤通路:GPCR/GProtein;NeuronalSignaling储存⽅式:4°C,sealedstorage,awayfrommoistureandlight*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoistureandlight)溶解性数据体外实验DMSO:250mg/mL(762.54mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM3.0502mL15.2509mL30.5018mL5mM0.6100mL3.0502mL6.1004mL10mM0.3050mL1.5251mL3.0502mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。BIOLOGICALACTIVITY⽣物活性Cyclopentolate(DL-Cyclopentolate)hydrochloride⼀种阿托品样毒蕈碱受体(muscarinicreceptor)拮抗剂，对睫状肌毒蕈碱受体的pKB值为7.8。Cyclopentolatehydrochloride眼科常⽤的抗毒蕈碱剂。体内研究Survivalinratspretreatedwithcyclopentolate(20mg/kg)is90%[3].AnimalModel:EightySprague-Dawleyrats(acute,lethalorganophosphatepesticide(OP)poisoning1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemEmodel)[3]Dosage:20mg/kg(Ophthalmiccyclopentolate)Administration:i.p.Result:Survivalinratspretreatedwithophthalmiccyclopentolate(20mg/kg)is90%.REFERENCES[1].ÖnerV,BulutA,ÖterK.Theeffectoftopicalanti-muscarinicagentsonsubfovealchoroidalthicknessinhealthyadults.Eye(Lond).2016;30(7):925‐928.[2].IshikawaH,DeSantisL,PatilPN.Selectivityofmuscarinicagonistsincluding(+/-)-aceclidineandantimuscarinicsonthehumanintraocularmuscles.JOculPharmacolTher.1998;14(4):363‐373.[3].ÖnerV,BulutA,ÖterK.Theeffectoftopicalanti-muscarinicagentsonsubfovealchoroidalthicknessinhealthyadults.Eye(Lond).2016;30(7):925‐928.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-37