SBFI-26-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESBFI-26Cat. No.: HY-117506BCAS No.: 1541207-06-0分式: CHO分量: 422.47作靶点: FABP作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (236.70 mM; Need ultrasonic

2、)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.3670 mL 11.8352 mL 23.6703 mL5 mM 0.4734 mL 2.3670 mL 4.7341 mL10 mM 0.2367 mL 1.1835 mL 2.3670 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄的储备液可以根据储存条件，适当保存；以下溶剂前

3、的百分指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.92 mM); Clear solutionBIOLOGICAL ACTIVITY物活性SBFI-26种选择性和竞争性的脂酸结合蛋 FABP5 和 FABP7 抑制剂， 对 FABP5 和 FABP7 作的 Ki 值1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE分别为 0.9 M 和 0.4 M。SBFI-26 具有抗伤害性和抗炎作 1 2。IC50 & Target Ki: 0.9

4、 M (FABP5), 0.4 M (FABP7) 1 2体外研究 SBFI-26 binds to the canonical ligand-binding pocket of FABP5 1.SBFI-26 significantly inhibits cellular AEA accumulation 2.体内研究 SBFI-26 (20 mg/kg, i.p.) significantly reduces carrageenan-induced thermal hyperalgesia and paw edema 2.SBFI-26 produces antinociceptive a

5、nd anti-inflammatory effects in mice 2.Animal Model: Mice 2Dosage: 20 mg/kgAdministration: Intraperitoneal injectionResult: Significantly reduced carrageenan-induced thermal hyperalgesia and paw edema.REFERENCES1. Berger WT, et al. Targeting fatty acid binding protein (FABP) anandamide transporters

6、- a novel strategy for development of anti-inflammatory and anti-nociceptive drugs. PLoS One. 2012;7(12):e50968.2. Hsu HC, et al. The Antinociceptive Agent SBFI-26 Binds to Anandamide Transporters FABP5 and FABP7 at Two Different Sites.Biochemistry. 2017 Jul 11;56(27):3454-3462.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400