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1、Gap1Gap2(cyclin kinase, Cdk)SGap1Gap2(cyclin kinase, Cdk)S未点 factorEGF、血小板衍生生长因子etderivedgrowthfactorPDGF长因子(transforminggrowthfactor, TGF,RNASRSR SRPK1,microRN487768776 1. Otto T, Sicinski P. Cell cycle proteins as s in therapy. NaturereviewsCancer2017;17(2): 93-2. Hydbring P, Malumbres M, Sicinski

2、 P. Non-canonical functions of cell cyclins and cyclin-dependent kinases. Nature reviews Molecular cell biology 17(5):280-s. Methods3. Barnum KJ, OConnell MJ. Cell cycle regulation by molecularbiology(Clifton,NJ)2014;1170:29-Tamura K. Development of cell-cycle therapy for solid journalofclinicalonco

3、logy2015;45(12):1097-XuJ,LiY,WangF,etal.SuppressedmiR-424viaupregulationof cervical cancer. gene Chk1 contributes to the 2013;32(8):976-6. Verlinden L, Vanden Bempt I, EelenG, et al. The E2F-regulated gene Chk1highly riple-negative estrogen receptor /progesterone 7. Xie Y,WeiRR, Huang GL, Zhang MY,

4、YuanYF,Wang HY. kinase 1 negatively regulated by miR-497 in hepatocellular carcinoma. Medical (Northwood, London, England) 2014; 31(3): 8. Manic G, Signore M, Sistigu A, et al. ed therapy to deplete replication-stressed,p53-deficient,hyperdiploid colorectalcancer stem negatively regulated by miR-497

5、 in hepatocellular carcinoma. Medical (Northwood, London, England) 2014; 31(3): 8. Manic G, Signore M, Sistigu A, et al. ed therapy to deplete replication-stressed,p53-deficient,hyperdiploid colorectalcancer stem Gut9. Guzi TJ, Paruch K, Dwyer MP, et ing the replication usingSCH 900776, a potent and

6、 functionallyselectiveCHK1 inhibitor via high content screening. Molecular cancerutics2011; 10(4): 591-10. Montano R, g I, Garner KM, Parry D, Eastman A. Preclinical of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging tabolites.Molecularcancerutics2012; 11(2): 427-11.SchenkEL,KohB

7、D,FlattenKS,etal.Effectsofselective1 inhibition on cytarabine cytotoxicity in acute myelogenous leukemia cells vitro.Clinicalcancerresearch:anljournaloftheAmericanCancerResearch2012; 18(19): 5364-KingC, DiazHB, McNeely S,et al. LY2606368 Causes Replication Mechanisms. Molecular Antitumor Effects through CHK1-utics2015; 14(9): 2004-13.Vijayaraghavan S, Karakas C, Doostan et al. CDK4/6 and inhibitors synergistically enescence itive cytoplasmic E negative cancers. Naturecommunications2017; 8: 14.Dom

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