DPA-714-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDPA-714Cat. No.: HY-122607CAS No.: 958233-07-3分式: CHFNO分量: 398.47作靶点: Others作通路: Others储存式: Please store the product under the recommended conditions inthe COA.溶解性数据体外实验 DMSO : 41.67 mg/mL (104.57 mM; Need ultrasonic)Mass Solven

2、t1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.5096 mL 12.5480 mL 25.0960 mL5 mM 0.5019 mL 2.5096 mL 5.0192 mL10 mM 0.2510 mL 1.2548 mL 2.5096 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分指该溶剂在您配制终

3、溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (5.22 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (5.22 mM); Clear solutionBIOLOGICAL ACTIVITY物活性DPA-714种亲和的移位蛋 (TSPO) 配体 (Ki=7 nM)，DPA-714 的结构中有个氟原，允许氟 -181/2 Master of Small Mol

4、ecules 您边的抑制剂师www.MedChemE进标记，并可使正电发射断层成像进活体成像。18FDPA-714 在各种神经炎症模型和脑肿瘤模型中成功评估炎症的特异性成像 1 2。IC50 & Target Ki: 7 nM (TSPO) 1REFERENCES1. James ML, et al. DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization. JNucl Med. 2008 May;49(5):814

5、-22.2. Harhausen D, et al. Specific imaging of inflammation with the 18 kDa translocator protein ligand DPA-714 in animal models of epilepsyand stroke. PLoS One. 2013 Aug 2;8(8):e69529.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-58955