Topiramate-McN-4853-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETopiramateCat. No.: HY-B0122CAS No.: 97240-79-4Synonyms: McN 4853; RWJ 17021分式: CHNOS分量: 339.36作靶点: mGluR作通路: GPCR/G Protein; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO

2、 : 100 mg/mL (294.67 mM)H2O : 4 mg/mL (11.79 mM; Need ultrasonic)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.9467 mL 14.7336 mL 29.4672 mL5 mM 0.5893 mL 2.9467 mL 5.8934 mL10 mM 0.2947 mL 1.4734 mL 2.9467 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。

3、体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.37 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)1/2 Master of Small M

4、olecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (7.37 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (7.37 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Topiramate是镇痉化合物，能拮抗GluR5受体，还可作为GABA受体介导的电流阳性变构调节剂。户使本产品发表的科研献 Personalized Medicine Universe. 2019 May.See more custome

5、r validations on HYPERLINK / www.MedChemEREFERENCES1. Lyseng-Williamson KA, et al. Topiramate: a review of its use in the treatment of epilepsy. Drugs. 2007;67(15):2231-56.2. Nakamura J, et al. Target pharmacology of topiramate, a new antiepileptic drug. Nihon Yakurigaku Zasshi. 2000 Jan;115(1):53-7.3. Ormrod D, et al. Topiramate: a review of its use in childhood epilepsy. Paediatr Drugs. 2001;3(4):293-319.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-379