RSV-IN-1 - RSV 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERSV-IN-1Cat. No.: HY-112673CAS No.: 861139-16-4分式: CHNOS分量: 427.48作靶点: RSV作通路: Anti-infection储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 125 mg/mL (292.41 mM; Need ultrasonic)H2O : 40%

2、PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (4.87 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (4.87 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 RSV-IN-1呼吸道合胞病毒 (hRSV) 的抑制剂，其 IC50 值为 0.11 M。IC50 & Target IC50: 0.1

3、1M (hRSV) 1.体外研究 The concentration of P13 that reduces the number of RSV plaques in HEp-2 cells by 50% (IC50) is 0.11 M.The concentration of P13 that reduces the viability of HEp-2 by 50% (CC50) is 310 M. Note that somecytotoxicity of P13 observed at 500 M might be due to DMSO solvent. Hence, the se

4、lective index(CC50/IC50) values is 2818 for P13. Note that even at the relatively high concentrations P13 does notcompletely block the development of RSV plaques. These escape plaques are of smaller size and of non-syncytial phenotype as compared to plaques formed in the absence of inhibitor 1.REFERENCES1. Lundin A, et al. Two novel fusion inhibitors of human respiratory syncytial virus. Antiviral Res. 2010 Dec;88(3):317-24.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;/p>