N-Acetyl-D-mannosamine-N-Acetylmannosamine-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEN-Acetyl-D-mannosamineCat. No.: HY-128850CAS No.: 3615-17-6Synonyms: N-Acetylmannosamine; ManNAc分式: CHNO分量: 221.21作靶点: Bacterial作通路: Anti-infection储存式: Please store the product under the recommended conditions inthe COA.溶解性数据体外实

2、验 H2O : 125 mg/mL (565.07 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 4.5206 mL 22.6030 mL 45.2059 mL5 mM 0.9041 mL 4.5206 mL 9.0412 mL10 mM 0.4521 mL 2.2603 mL 4.5206 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 N-Acetyl-D-mannosamine (ManNAc) N-酰-

3、D-露糖胺 N-酰神经氨酸 (NeuAc) 的必需前体，细菌荚膜聚唾液酸(PA) 的特异性单体。N-Acetyl-D-mannosamine (ManNAc) N-酰 -D-露糖胺分别通过 GNE 和GlcNAc 2-差向异构酶 (肾素结合蛋，RnBP) 代谢成 ManNAc-6-磷酸和 GlcNAc。N-Acetyl-D-mannosamine(ManNAc) N-酰 -D-露糖胺及其衍物激活欲素神经元中的 hypocretin (HCRT)基因表达，为神经疾病的治疗提供了潜在的可能。REFERENCES1/2 Master of Small Molecules 您边的抑制剂师www.Med

4、ChemE1. Revilla-Nuin B, et al. Transport of N-acetyl-D-mannosamine and N-acetyl-D-glucosamine in Escherichia coli K1: effect on capsularpolysialic acid production. FEBS Lett. 2002 Jan 30;511(1-3):97-101.2. Hayakawa K, et al. Reactivation of hyperglycemia-induced hypocretin (HCRT) gene silencing by N-acetyl-d-mannosamine in the orexinneurons derived from human iPS cells. Epigenetics. 2017 Sep;12(9):764-778.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;/p>