A-366 - Histone Methyltransferase 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEA-366Cat. No.: HY-12583CAS No.: 1527503-11-2分式: CHNO分量: 329.44作靶点: Histone Methyltransferase作通路: Epigenetics储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 50 mg/mL (151.77 mM; Need ultraso

2、nic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.0355 mL 15.1773 mL 30.3545 mL5 mM 0.6071 mL 3.0355 mL 6.0709 mL10 mM 0.3035 mL 1.5177 mL 3.0355 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；

3、以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.59 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (7.59 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 A-

4、366有效的组蛋甲基转移酶G9a抑制剂，IC50 为3.3 nM。户使本产品发表的科研献 Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2961-2966. Theranostics. 2018 Apr 15;8(10):2884-2895.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Pappano WN, et al. The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia.PLoSOne. 2015 Jul 6;10(7):e0131716.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;F