PF-3845 - FAAH 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPF-3845Cat. No.: HY-14380CAS No.: 1196109-52-0分式: CHFNO分量: 456.46作靶点: FAAH作通路: Metabolic Enzyme/Protease; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (219.08

2、 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.1908 mL 10.9539 mL 21.9077 mL5 mM 0.4382 mL 2.1908 mL 4.3815 mL10 mM 0.2191 mL 1.0954 mL 2.1908 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体

3、内实验的作液，建议您现现配，当天使；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.48 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.48 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/

4、2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (5.48 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 PF-3845选择性脂 酰胺解酶（FAAH）抑制剂，Ki为230nM，对FAAH2乎活性。REFERENCES1. Ahn K, et al. Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chem Biol.

5、2009 Apr24;16(4):411-20.2. Booker L, et al. The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactileallodynia in mice. Br J Pharmacol, 2012, 165(8), 2485-2496.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-589