Fostamatinib-Disodium-R788-Disodium-DataSheet-生命科学试剂-MedChemExpressVIP

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEFostamatinib DisodiumCat. No.: HY-13038CAS No.: 1025687-58-4Synonyms: R788(Disodium)分式: CHFNNaOP分量: 624.42作靶点: Syk作通路: Protein Tyrosine Kinase/RTK储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DM

2、SO : 50 mg/mL (80.07 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.6015 mL 8.0074 mL 16.0149 mL5 mM 0.3203 mL 1.6015 mL 3.2030 mL10 mM 0.1601 mL 0.8007 mL 1.6015 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验

3、的作液，建议您现现配，当天使；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (4.00 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (4.00 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLO

4、GICAL ACTIVITY物活性 Fostamatinib Disodium (R788 Disodium)活性代谢物R406的原药，Syk抑制剂，IC50为41 nM。IC50 & Target IC50 Value: 41 nM 1Target: Syk户使本产品发表的科研献 Nat Med. 2018 Feb;24(2):232-238. Cancer Cell. 2014 Feb 10;25(2):226-42. Sci Transl Med. 2018 Jul 18;10(450). pii: eaaq1093. Blood Cancer J. 2014 Aug 22;4:e240

5、.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Braselmann, S., et al., R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immunecomplex-mediated inflammation. J Pharmacol Exp Ther, 2006. 319(3): p. 998-1008.2. Chen, L., et al.,

6、 SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma. Blood,2008. 111(4): p. 2230-7.3. Suljagic, M., et al., The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Emu- TCL1 transgenic mouse model ofCLL by blocking antigen-dependent B-cell receptor signaling. Blood, 2010. 116(23): p. 4894-905.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel