Kainic-acid - Acids and Aldehyde - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEKainic acidCat. No.: HY-N2309CAS No.: 487-79-6分式: CHNO分量: 213.23作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 H2O : 50 mg/mL (234.49 mM)* means soluble, but saturation unkn

2、own.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 4.6898 mL 23.4489 mL 46.8977 mL5 mM 0.9380 mL 4.6898 mL 9.3795 mL10 mM 0.4690 mL 2.3449 mL 4.6898 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Kainic acidCNS 中兴奋性氨酸受体亚型的有效激动剂。体内研究Kainic acid is a potent agonist at excitat

3、ory amino acid receptor subtypes in the CNS. HO-I levels aresignificantly enhanced one, three and seven days after i.c.v, injection of Kainic acid. One day after i.c.v,injection of Kainic acid, the HO-I protein level reaches a maximum and then decreases, but is stillsignificantly enhanced versus the

4、 vehicle-injected group. After i.c.v. injection of Kainic acid, HO-I-1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEimmunoreactivity is strongly induced not only in the CA3 but also widely in the whole hippocampus 1.PROTOCOLAnimal The rats are fasted over night with free access to water. For stere

5、otaxic injection, rats are anaesthetizedAdministration 1 (sodium pentobarbital, 50 mg/kg, i.p.) and immobilized in a Kopf stereotaxic frame. The rats are microinjectedwith 1 g Kainic acid in 2 L of sterilized physiological saline into the right lateral ventricle, i.e., 0.2 mmcaudal from the bregma,

6、1.2 mm right lateral and 3.8 mm ventral according to the rat brain atlas. For control,rats are injected with same amount (2 L) of vehicle, sterilized physiological saline. Five rats in each groupare used in this study 1.MCE has not independently confirmed the accuracy of these methods. They are for reference only.REFERENCES1. Matsuoka Y, et al. Kainic acid induction of heme oxygenase in vivo and in vitro. Neuroscience. 1998 Aug;85(4):1223-33.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.