Hydrocortisone-cypionate - Glucocorticoid Receptor Agonist - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEHydrocortisone cypionateCat. No.: HY-U00089CAS No.: 508-99-6分式: CHO分量: 486.64作靶点: Glucocorticoid Receptor作通路: GPCR/G Protein储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 125 mg/mL (256.86

2、 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.0549 mL 10.2745 mL 20.5491 mL5 mM 0.4110 mL 2.0549 mL 4.1098 mL10 mM 0.2055 mL 1.0275 mL 2.0549 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄的储备

3、液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (4.27 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (4.27 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL

4、 (4.27 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 Hydrocortisone cypionate种合成的糖质激素和质类醇酯。体外研究 Hydrocortisone (50 nM) shows a dose-dependent down-regulation of GR transcript in hCMEC/D3 cells.Hydrocortisone supplementation of the serum-reduced cell diffe

5、rentiation medium leads to a significantincrease in TER across the hCMEC/D3 monolayer 1. Hydrocortisone-treated Dendritic cells (DCs) show adecreased expression of MHC II molecules, the costimulatory molecule CD86, and the DC-specific markerCD83, as well as a strongly reduced IL-12 secretion. Hydroc

6、ortisone-treated DCs inhibit production of IFN-but induce an increased release of IL-4 and no change in IL-5 2. Hydrocortisone reduces postischemicoxidative stress, perfusion pressure, and transudate formation. Hydrocortisone inhibits postischemicshedding of syndecan-1, heparan sulfate, and hyaluron

7、an as is release of histamine from resident mast cells3.REFERENCES1. F?rster C, et al. Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol. 2008 Apr 1;586(7):1937-49.2. Bellinghausen I, et al. Inhibition of h

8、uman allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol. 2001 Aug;108(2):242-9.3. Chappell D, et al. Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology. 2007Nov;107(5):776-84.McePdfHeightCaution: Product has not been fully validated for medical application