APD597-JNJ-38431055-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAPD597Cat. No.: HY-15566CAS No.: 897732-93-3Synonyms: JNJ-38431055分式: CHNOS分量: 479.55作靶点: GPR119作通路: GPCR/G Protein; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 19 mg/

2、mL (39.62 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.0853 mL 10.4264 mL 20.8529 mL5 mM 0.4171 mL 2.0853 mL 4.1706 mL10 mM 0.2085 mL 1.0426 mL 2.0853 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 APD597 is prepare in vehicle (distilled water)3

3、.BIOLOGICAL ACTIVITY物活性 APD597GPR119激动剂, 作于hGPR119, EC50为46 nM, 可于治疗2型糖尿病。1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE户使本产品发表的科研献 Sci Rep. 2017 Jun 28;7(1):4351.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Buzard DJ, et al. Discovery and optimization of 5-fluoro-4,6-dia

4、lkoxypyrimidine GPR119 agonists. Bioorg Med Chem Lett. 2014 Sep1;24(17):4332-4335.2. Semple G, et al. Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improvedprofile.Bioorg Med Chem Lett. 2012 Feb 15;22(4):1750-1755.3. Huan Y, et al. The dual DPP4 inhibitor and GPR119 agonist HBK001 regulates glycemic control and beta cell function ex and in vivo. SciRep. 2017 Jun 28;7(1):4351.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;/p>