THAL-SNS-032 - PROTAC - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETHAL-SNS-032Cat. No.: HY-123937CAS No.: 2139287-33-3分式: CHNOS分量: 869.02作靶点: PROTAC; CDK作通路: PROTAC; Cell Cycle/DNA Damage储存式: -20C, stored under nitrogen* In solvent : -80C, 6 months; -20C, 1 month (stored undernitrogen)溶解性数据体外实

2、验 DMSO : 100 mg/mL (115.07 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.1507 mL 5.7536 mL 11.5072 mL5 mM 0.2301 mL 1.1507 mL 2.3014 mL10 mM 0.1151 mL 0.5754 mL 1.1507 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可

3、靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (2.88 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (2.88 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of

4、 Small Molecules 您边的抑制剂师www.MedChemE物活性 THAL-SNS-032种选择性的 CDK 降解剂，由 CDK 配体 SNS-032，E3 连接酶 (CRBN) 的配体 thalidomide 衍物和个 linker 组成 PROTAC 连接体 1。IC50 & Target CDK9 1体外研究 THAL-SNS-032 selectively induces degradation of CDK9 1.THAL-SNS-032 diminishes elongating polymerase II 1.THAL-SNS-032 inhibits prolif

5、eration of MOLT4 cells with an IC50 of 50 nM 1.REFERENCES1. Olson CM，et al. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nat Chem Biol. 2018Feb;14(2):163-170.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-5895