Nitrendipine-BAY-E-5009-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemENitrendipineCat. No.: HY-B0424CAS No.: 39562-70-4Synonyms: BAY-E-5009分式: CHNO分量: 360.36作靶点: Calcium Channel; Autophagy作通路: Membrane Transporter/Ion Channel; Neuronal Signaling;Autophagy储存式: 4C, protect from light* In solvent : -

2、80C, 6 months; -20C, 1 month (protect fromlight)溶解性数据体外实验 DMSO : 50 mg/mL (138.75 mM; Need ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.94 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (6.94 mM); Clear solution1/2 Master of Small Molecules

3、您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 Nitrendipine钙离通道阻断剂，有管舒张活性。REFERENCES1. Bean, B.P., Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state. Proc Natl Acad Sci U S A, 1984.81(20): p. 6388-92.2. Peterson, B.Z., T.N. Tanada, and W.A. Catterall, Molecula

4、r determinants of high affinity dihydropyridine binding in L-type calciumchannels. J Biol Chem, 1996. 271(10): p. 5293-6.3. Bellemann, P., et al., 3H-Nitrendipine, a potent calcium antagonist, binds with high affinity to cardiac membranes.Arzneimittelforschung, 1981. 31(12): p. 2064-7.4. Bolger, G.T

5、., et al., Characterization of binding of the Ca+ channel antagonist, 3Hnitrendipine, to guinea-pig ileal smooth muscle. JPharmacol Exp Ther, 1983. 225(2): p. 291-309.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-589559