Endoxifen-Z-isomer-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEEndoxifen Z-isomerCat. No.: HY-18719CAS No.: 112093-28-4分式: CHNO分量: 373.49作靶点: Estrogen Receptor/ERR; Potassium Channel作通路: Others; Membrane Transporter/Ion Channel储存式: Please store the product under the recommended conditions i

2、nthe COA.溶解性数据体外实验 DMSO : 50 mg/mL (133.87 mM; Need ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.69 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (6.69 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物

3、活性 Endoxifen Z-isomer最重 的Tamoxifen代谢产物, 诱导在表达ER的乳腺癌细胞中发挥抗雌激素作,Endoxifen Z-isomer抑制hERG, 这种作具有浓度依赖性, IC50值为1.6M。户使本产品发表的科研献 North Dakota State University of Agriculture and Applied Science. 2018 Feb.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Chae YJ, et al. Endoxifen, the a

4、ctive metabolite of tamoxifen, inhibits cloned hERG potassium channels. Eur J Pharmacol. 2015 Apr5;752:1-7.2. Wu X, et al. Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen. Breast Cancer Res. 2011Mar 10;13(2):R27.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 02