GSK2795039 - NOX2 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEGSK2795039Cat. No.: HY-18950CAS No.: 1415925-18-6分式: CHNOS分量: 450.56作靶点: NADPH Oxidase; ROS作通路: Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实

2、验 DMSO : 32 mg/mL (71.02 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.2195 mL 11.0973 mL 22.1946 mL5 mM 0.4439 mL 2.2195 mL 4.4389 mL10 mM 0.2219 mL 1.1097 mL 2.2195 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 GSK2795039种 NA

3、DPH 氧化酶 2 (NOX2) 抑制剂，在不同的细胞试验中平均 pIC50 为 6，抑制活性氧ROS 产和 NADPH 消耗。GSK2795039 可减少细胞凋亡 (apoptosis)。体外研究GSK2795039 (25 M; 24 hours) reduces the combinatory effect of FeSO4 and LPS-increased levels ofapoptosis and reduced the presence of caspase-3-positive PC12 cells 2.Apoptosis Analysis 21/2 Master of Sm

4、all Molecules 您边的抑制剂师www.MedChemECell Line: PC12 cellsConcentration: 25 MIncubation Time: 24 hoursResult: Reduced apoptosis among PC12 cells.体内研究 GSK2795039 (intraperitoneal injection; 100 mg/kg; 1 hour before) decreases activity in a murine model ofacute pancreatitis, reducing the levels of serum a

5、mylase triggered by systemic injection of cerulein 1.Animal Model: C57BL6 mice 1Dosage: 100 mg/kgAdministration: Intraperitoneal injection; 100 mg/kg; 1 hour beforeResult: Caused 50% reduction in the level of serum amylase activity.户使本产品发表的科研献 Ann Neurol. 2019 Jun;85(6):907-920. Redox Biol. 2018 Dec

6、 12:101075. Oxid Med Cell Longev. 2019 Apr 28;2019:2717986. Endocrinology. 2019 Apr 1;160(4):947-963.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Hirano K, et al. Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor. Antioxid Redox Signal. 2015 Aug10;23(

7、5):358-74.2. Yauger YJ, et al. Iron accentuated reactive oxygen species release by NADPH oxidase in activated microglia contributes to oxidativestress in vitro. J Neuroinflammation. 2019 Feb 18;16(1):41.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use on