LY2452473 - Androgen Receptor Modulator - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELY2452473Cat. No.: HY-114530CAS No.: 1029692-15-6分式: CHNO分量: 374.44作靶点: Androgen Receptor作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 62.5 mg/mL (166.92 mM; Need ultrasonic)Ma

2、ss Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.6707 mL 13.3533 mL 26.7065 mL5 mM 0.5341 mL 2.6707 mL 5.3413 mL10 mM 0.2671 mL 1.3353 mL 2.6707 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的

3、百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (5.55 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (5.55 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 LY2452473种服物可利的选择性雄激素受体 (an

4、drogen receptor) 调节剂 (SARM)。IC50 & Target Androgen receptor 1体内研究 LY2452473 is a selective androgen receptor modulator being developed for the treatment of disordersrelated to hypogonadism. LY2452473 is absorbed rapidly (time to reach maximum plasma concentration forboth LY2452473 and total radioact

5、ivity is 2-3 h) and cleared slowly (plasma terminal t1/2 of 27 h forLY2452473 and 51 h for the total radioactivity) 1.REFERENCES1. Yi P, et al. Disposition and metabolism of LY2452473, a selective androgen receptor modulator, in humans. Drug Metab Dispos. 2012Dec;40(12):2354-64.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-