Selisistat-S-enantiomer-EX-527-S-enantiomer-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESelisistat S-enantiomerCat. No.: HY-15452ACAS No.: 848193-68-0Synonyms: EX-527 (S-enantiomer)分式: CHClNO分量: 248.71作靶点: Sirtuin作通路: Cell Cycle/DNA Damage; Epigenetics储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1

2、 month溶解性数据体外实验 DMSO : 100 mg/mL (402.07 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 4.0207 mL 20.1037 mL 40.2075 mL5 mM 0.8041 mL 4.0207 mL 8.0415 mL10 mM 0.4021 mL 2.0104 mL 4.0207 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当

3、的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (10.05 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (10.05 mM); Clear s

4、olution1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (10.05 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Selisistat S-enantiomer (EX-527 S-enantiomer)是Selisistat 的 S 对映体，可以有效抑制 SIRT1 的活性，IC50值为 123 nM。Selisistat S-enantiomer 的活性 Selisistat R-e

5、nantiomer 很多。IC50 & Target SIRT1123 nM (IC50)REFERENCES1. Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec15;48(25):8045-54.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-5895