plus-Bicuculline-d-Bicuculline-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE(+)-BicucullineCat. No.: HY-N0219CAS No.: 485-49-4Synonyms: d-Bicuculline分式: CHNO分量: 367.35作靶点: GABA Receptor作通路: Membrane Transporter/Ion Channel; Neuronal Signaling储存式: 4C, protect from light* In solvent : -80C, 6 months; -20C

2、, 1 month (protect fromlight)溶解性数据体外实验 DMSO : 36 mg/mL (98.00 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.7222 mL 13.6110 mL 27.2220 mL5 mM 0.5444 mL 2.7222 mL 5.4444 mL10 mM 0.2722 mL 1.3611 mL 2.7222 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。

3、体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.81 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL

4、 (6.81 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (6.81 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 (+)-Bicuculline是对光敏感的GABA-A 受体竞争型拮抗剂。户使本产品发表的科研献 J Pain. 2019 May;20(5):577-591.See more customer validations on HYPERLI

5、NK / www.MedChemEREFERENCES1. Zahm DS, et al. Comparison of the locomotor-activating effects of bicuculline infusions into the preoptic area and ventral pallidum. BrainStruct Funct. 2014 Mar;219(2):511-26.2. Johnston GA. Advantages of an antagonist: bicuculline and other GABA antagonists. Br J Pharmacol. 2013 May;169(2):328-36.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 0