Imisopasem-manganese-M40403-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEImisopasem manganeseCat. No.: HY-13336CAS No.: 218791-21-0Synonyms: M40403分式: CHClMnN-分量: 538.32作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 H2O : 16 mg/mL (29.72 mM; Need

2、 ultrasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.8576 mL 9.2882 mL 18.5763 mL5 mM 0.3715 mL 1.8576 mL 3.7153 mL10 mM 0.1858 mL 0.9288 mL 1.8576 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Imisopasem manganese (M40403)稳定的MnSOD的肽基模拟物。体外研究 M40403 is

3、a small molecule, synthetic manganese containing superoxide dismutase mimetic (SODm) thatremoves superoxide anions without interfering with other reactive species known to be involved ininflammatory responses (e.g. nitric oxide, NO and peroxynitrite, ONOO-) 1.1/2 Master of Small Molecules 您边的抑制剂师www

4、.MedChemE体内研究 M40403 is a small-molecule superoxide dismutase mimetic that has shown efficacy in animal model diseasestates in which superoxide anions are thought to play a key role. M40403 inhibits the inflammatory responsefollowing the intrapleural injection of carrageenan in rats. All parameters

5、of inflammation are attenuated byM40403 except for NOx, PGE2 and IL-10 which remains unaltered 1. Decreased apoptosis of the large andparticularly the small bowel and marked recovery of both lymphoid and hematopoietic tissues occurs in theM40403 pre-treated mice. M40403 is effective in reducing TBI-

6、induced tissue destruction and has potentialas a new radioprotective agent 2.PROTOCOLAnimal Rats: Male Sprague-Dawley rats are used in the study. M40403 (5-20mgkg-1), or an equivalent volume (0.3Administration 12 mL) of vehicle (26mm sodium bicarbonate buffer, pH8.1-8.3), is injected intraperitoneal

7、ly (i.p.) 15min beforecarrageenan. At 4h after the injection of carrageenan, the animals are killed by inhalation of CO2 1.Mice: 30 mg dry powder M40403 is dissolved in 6.0 ml SBC adjusted to pH 8.3 with 1 M NaOH. This stocksolution is diluted to 1.25 mg/mL in SBC. Two experimental models are tested

8、. In one, the dose of IR is heldconstant at 8.5 Gy total body irradiation (TBI). The mice are injected i.p. with a single dose of 40 mg/kg, 30mg/kg, 20 mg/kg or 10 mg/kg M40403. Thirty minutes later the mice receives 8.5 Gy total body irradiation(TBI). Control animals receives 0.1 ml of SBC buffer p

9、rior to TBI. In the other model, groups of 20 micereceives either 6.5 or 7.5 Gy TBI. One half of each group is treated with 2.0 mg/kg M40403 i.p. and the otherwith SBC 30 min before TBI. All are followed for survival 2.MCE has not independently confirmed the accuracy of these methods. They are for r

10、eference only.REFERENCES1. Salvemini D, et al. Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic,M40403. Br JPharmacol. 2001 Feb;132(4):815-27.2. Masini E, et al. Protective effects of M40403, a selective superoxide dismutase mimetic, in myocardial ischaemia and reperfusion injuryin vivo. Br J Pharmacol. 2002 Jul;136(6):905-17.McePdfHeightCaution: Product has not been fully