Balapiravir-Ro-4588161-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBalapiravirCat. No.: HY-10443CAS No.: 690270-29-2Synonyms: Ro 4588161; R1626分式: CHNO分量: 494.5作靶点: HCV作通路: Anti-infection储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (202.22 mM)

2、* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.0222 mL 10.1112 mL 20.2224 mL5 mM 0.4044 mL 2.0222 mL 4.0445 mL10 mM 0.2022 mL 1.0111 mL 2.0222 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验

3、的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.06 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.06 mM); Clear solution1/2 Master of Small Molecules 您边的抑制剂师ww

4、w.MedChemE3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.06 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Balapiravir (R1626, Ro 4588161)是R1479（RG1479）的原药，是HCV的RNA聚合酶核苷类似物抑制剂。户使本产品发表的科研献 J Infect Dis. 2016 Sep 1;214(5):707-11. Antivir Res. 2019 Jul. Antiviral Res. 2016 Sep;133:119-29.See mo

5、re customer validations on HYPERLINK / www.MedChemEREFERENCES1. Nguyen NM, et al. A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients. JInfect Dis. 2013 May 1;207(9):1442-1450.2. Nelson DR, et al. Balapiravir plus peginterferon alfa-2a

6、 (40KD)/ribavirin in a randomized trial of hepatitis C genotype 1 patients.AnnHepatol. 2012 Jan-Feb;11(1):15-31.3. Li F, et al. Chemical stability of 4-azidocytidine and its prodrug balapiravir.Drug Dev Ind Pharm. 2010 Apr;36(4):413-20.4. kros PJ, et al. R1626 plus peginterferon Alfa-2a provides pot

7、ent suppression of hepatitis C virus RNA and significant antiviral synergy incombination with ribavirin.Hepatology. 2008 Aug;48(2):385-97.5. Roberts SK, et al. Robust antiviral activity of R1626, a novel nucleoside analog: a randomized, placebo-controlled study in patients withchronic hepatitis C.Hepatology. 2008 Aug;48(2):398-406.6. Chen YL, et al. Activation of peripheral blood mononuclear cells by dengue virus infection depotentiates balapiravir. J Virol. 2014Feb;88(3):1740-1747.McePdfHeightCaution: Product has not been fully validated for medical applications.For r