LY2979165 _mGluR Agonist - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELY2979165Cat. No.: HY-13239CAS No.: 1311385-32-6分式: CHNOS分量: 390.42作靶点: mGluR作通路: GPCR/G Protein; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 H2O : 50 mg/mL (128.07 mM)DMSO :

2、 90% (20% SBE-CD in saline)Solubility: 0.1 mg/mL (0.26 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE物活性 LY2979165是mGlu2激动剂，是抗抑郁新型化合物。REFERENCES1. /ct2/show/NCT013839672. Hanna L, Ceolin L, Lucas S, Monn J, Johnson B, Collingridge G, Bortolotto Z, Lodge D.Dif

3、ferentiating the roles of mGlu2 and mGlu3receptors using LY541850, an mGlu2 agonist/mGlu3 antagonist.Neuropharmacology. 2012 Mar 15.3. Ceolin L, Kantamneni S, Barker GR, Hanna L, Murray L, Warburton EC, Robinson ES, Monn JA, Fitzjohn SM, Collingridge GL,Bortolotto ZA, Lodge D.Study of novel selectiv

4、e mGlu2 agonist in the temporo-ammonic input to CA1 neurons reveals reduced mGlu2recepto4. Liu W, Downing AC, Munsie LM, Chen P, Reed MR, Ruble CL, Landschulz KT, Kinon BJ, Nisenbaum LK.Pharmacogenetic analysis ofthe mGlu2/3 agonist LY2140023 monohydrate in the treatment of schizophrenia.Pharmacogen

5、omics J. 2012 Jun;12(3):246-54.5. Dominguez C, Prieto L, Valli MJ, Massey SM, Bures M, Wright RA, Johnson BG, Andis SL, Kingston A, Schoepp DD, Monn JA.Methylsubstitution of 2-aminobicyclo3.1.0hexane 2,6-dicarboxylate (LY354740) determines functional activity at metabotropic glutamateMcePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-