Methyl-gallate-Gallincin-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMethyl gallateCat. No.: HY-N2010CAS No.: 99-24-1Synonyms: Gallincin; NSC 363001分式: CHO分量: 184.15作靶点: Bacterial; Reactive Oxygen Species作通路: Anti-infection; Immunology/Inflammation; MetabolicEnzyme/Protease; NF-B储存式: Powder -20C

2、3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 160 mg/mL (868.86 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 5.4304 mL 27.1518 mL 54.3036 mL5 mM 1.0861 mL 5.4304 mL 10.8607 mL10 mM 0.5430 mL 2.7152 mL 5.4304 mL请根据产品在不同溶剂中的溶解度，选

3、择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Methyl gallate是具有抗氧化，抗癌和抗炎活性的植物酚类。Methyl gallate也可抑制细菌活性。IC50 & Target Bacterial 11/2 Master of Small Molecules 您边的抑制剂师www.MedChemE体外研究 The growth of A. viscosus is inhibited completely by a low dose of Methyl gallate (MIC=1 mg/mL). S. mutansand . so

4、brinus show intermediate sensitivity to Methyl gallate (MIC=2-4 mg/mL), whereas the growth ofLactobacillus spp. is inhibited completely at a relatively high concentration (MIC=8 mg/mL) 1. Methyl gallate,in a concentration of 100 mM, could alleviate lipid peroxidation of the cells exposed to a short-

5、term H2O2treatment. In addition, Methyl gallate-treated cells could prevent intracellular glutathione (GSH) from beingdepleted following an exposure of H2O2 (8.0 mM) for a 3 h period 2. Methyl gallate inhibits Treg cell-suppressive effects on effector CD4+ T cells and Treg migration toward tumor env

6、ironment. Furthermore,forkhead box P3 (Foxp3) expression is also significantly decreased by methyl gallate 3.PROTOCOLCell Assay 1 KB cells, a human mouth epithelial cell line, are treated with Methyl gallate (1-8 mg/mL) for 24 h. Cytotoxicityof Methyl gallate is assessed by a modified MTT assay 1.MC

7、E has not independently confirmed the accuracy of these methods. They are for reference only.REFERENCES1. Kang MS, et al. Inhibitory effect of methyl gallate and gallic acid on oral bacteria. J Microbiol. 2008 Dec;46(6):744-50.2. Hsieh TJ, et al. Protective effect of methyl gallate from Toona sinens

8、is (Meliaceae) against hydrogen peroxide-induced oxidative stressand DNA damage in MDCK cells. Food Chem Toxicol. 2004 May;42(5):843-50.3. Lee H, et al. Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells. JImmunol. 2010 Dec 1;185(11):6698-705.McePdfHeightCaution: Product has not been fully validated for medical application