DCPIB _VRAC Blocker - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDCPIBCat. No.: HY-103371CAS No.: 82749-70-0分式: CHClO分量: 427.36作靶点: Chloride Channel; Potassium Channel作通路: Membrane Transporter/Ion Channel储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 12

2、5 mg/mL (292.49 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.3399 mL 11.6997 mL 23.3995 mL5 mM 0.4680 mL 2.3399 mL 4.6799 mL10 mM 0.2340 mL 1.1700 mL 2.3399 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助

3、溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (4.87 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (4.87 mM); Clear solution; Need ultrasonic3

4、. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.08 mg/mL (4.87 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 DCPIB种选择性、可逆、有效的体积调节性 离通道 (VRAC) 抑制剂，能够电压依赖性激活钾离通道TREK1 和 TRAAK，抑制 TRESK，TASK1 和 TASK3，IC50 值分别为 0.14，0.95，50.72 M 1。DCPIB 同时抑制肿胀激活氯电流 (ICl,swell)

5、，在 CPAE 细胞中，IC50 值为 4.1 M 2。IC50 & Target IC50：0.14 M (TRESK), 0.95 M (TASK1), 50.72 M (TASK3) 1, 4.1 M (ICl,swell, CPAE cells) 2REFERENCES1. Lv J, et al. DCPIB, an Inhibitor of Volume-Regulated Anion Channels, Distinctly Modulates K2P Channels. ACS Chem Neurosci. 2019Apr 17.2. Decher N, et al. DCPIB is a novel selective blocker of I(Cl,swell) and prevents swelling-induced shortening of guinea-pig atrial actionpotential duration. Br J Pharmacol. 2001 Dec;134(7):1467-79.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-