AWZ1066S _Anti-Wolbachia Drug - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAWZ1066SCat. No.: HY-114415CAS No.: 2239272-16-1分式: CHFNO分量: 404.39作靶点: Parasite作通路: Anti-infection储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 125 mg/mL (309.11 mM; Need ultrasonic)Mass

2、 Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.4729 mL 12.3643 mL 24.7286 mL5 mM 0.4946 mL 2.4729 mL 4.9457 mL10 mM 0.2473 mL 1.2364 mL 2.4729 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分

3、 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (5.14 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (5.14 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (5.14 mM); Clear solut

4、ion1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 AWZ1066S种度特异性的抗 Wolbachia 的候选药物，可于丝病的短期治疗，其在细胞中测得的EC50 值为 2.5 nM。REFERENCES1. Hong WD, et al. AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis. Proc Natl Acad SciU S A. 2019 Jan 22;116(4):1414-1419.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: