Ogerin-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEOgerinCat. No.: HY-110279CAS No.: 1309198-71-7分式: CHNO分量: 307.35作靶点: Others作通路: Others储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 250 mg/mL (813.40 mM; Need ultrasonic)Mass Solvent1 mg

2、5 mg 10 mg Concentration制备储备液1 mM 3.2536 mL 16.2681 mL 32.5362 mL5 mM 0.6507 mL 3.2536 mL 6.5072 mL10 mM 0.3254 mL 1.6268 mL 3.2536 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中

3、的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (6.77 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (6.77 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (6.77 mM); Clear solution1/2 Master

4、 of Small Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 Ogerin种选择性的 GPR68 正向别构调节剂，pEC50 值为 6.83。Ogerin 对 A2A 受体具有适中的拮抗作，Ki 值为 220 nM；对 5-HT2B 受体的拮抗作较弱，Ki 值为 736 nM。Ogerin 抑制对恐惧记忆的回忆1。IC50 & Target pEC50: 6.83 (GPR68) 1Ki: 220 nM (A2A receptoor), 736 nM (5-HT2B receptor) 1REFERENCES1. Huang XP, et al. Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Nature. 2015 Nov 26;527(7579):477-83.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;/p>