ML-098-CID-7345532-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEML-098Cat. No.: HY-19800CAS No.: 878978-76-8Synonyms: CID-7345532分式: CHNO分量: 309.36作靶点: Ras作通路: GPCR/G Protein储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 29 mg/mL (93.74 mM)* means solu

2、ble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.2325 mL 16.1624 mL 32.3248 mL5 mM 0.6465 mL 3.2325 mL 6.4650 mL10 mM 0.3232 mL 1.6162 mL 3.2325 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 ML-098（CID-7345532）GTP结合蛋Rab7的激活剂，EC50值为77.6nM。IC50 &

3、Target EC50: 77.6 nM (Rab7) 1体外研究Probe compound mL098 (CID-7345532) functions by increasing the affinity of the GTPases for guanine1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEnucleotides, leading to the hypothesis that these activators interact with GTPases bind to an allostericbinding site loc

4、alized between switch regions I and II. ML-098 is an activator of the GTP-binding protein Rab7with an EC50 of 77.6 nM which shows selectivity against the related GTPases cdc42, Ras, Rab-2A, andRac1 (EC50s = 588.8, 346.7, 158.5, and 794.3 nM, respectively) 1.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 02