L-5-Hydroxytryptophan-L-5-HTP-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEL-5-HydroxytryptophanCat. No.: HY-B1716CAS No.: 4350-09-8Synonyms: L-5-HTP; Oxitriptan分式: CHNO分量: 220.22作靶点: Endogenous Metabolite作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 mon

2、th溶解性数据体外实验 DMSO : 100 mg/mL (454.09 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 4.5409 mL 22.7046 mL 45.4091 mL5 mM 0.9082 mL 4.5409 mL 9.0818 mL10 mM 0.4541 mL 2.2705 mL 4.5409 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶

3、剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (11.35 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (11.35 mM); Clear solution1/2 Master of Small

4、 Molecules 您边的抑制剂师www.MedChemEBIOLOGICAL ACTIVITY物活性 L-5-Hydroxytryptophan (L-5-HTP)种天然氨 酸和膳补充剂，可作为抗抑郁剂、欲抑制剂和睡眠辅助剂， 神经递质 素的前体， 利平 (reserpine) 的拮抗剂。L-5-Hydroxytryptophan (L-5-HTP) 可于治疗纤维肌痛症、肌阵挛、偏头痛和脑共济失调 2 3 4 5。IC50 & Target Human Endogenous MetaboliteREFERENCES1. ARVID CARLSSON, et al. 3,4-Dihydrox

5、yphenylalanine and 5-Hydroxytryptophan as Reserpine Antagonists. Nature 180, page1200(1957).2. Caruso I, et al. Double-blind study of 5-hydroxytryptophan versus placebo in the treatment of primary fibromyalgia syndrome. J Int MedRes. 1990 May-Jun;18(3):201-9.3. Thal LJ, et al. Treatment of myoclonus

6、 with L-5-hydroxytryptophan and carbidopa: clinical, electrophysiological, and biochemicalobservations. Ann Neurol. 1980 Jun;7(6):570-6.4. Boiardi A, et al. 5-OH-Tryptophane in migraine: clinical and neurophysiological considerations. J Neurol. 1981;225(1):41-6.5. Trouillas P, et al. Improvement of cerebellar ataxia with levorotatory form of 5-hydroxytryptophan. A double-blind study with quantifieddata processing. Arch Neurol. 1988 Nov;45(11):1217-22.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only