Indoleamine-2-3-Dioxygenase-IDO-Inhibitors-Modulators-MCE

1、 HYPERLINK https:/www.MedChemE/Targets/Indoleamine 2,3-Dioxygenase (IDO).html Indoleamine HYPERLINK https:/www.MedChemE/Targets/Indoleamine 2,3-Dioxygenase (IDO).html HYPERLINK https:/www.MedChemE/Targets/Indoleamine 2,3-Dioxygenase (IDO).html 2,3-Dioxygenase HYPERLINK https:/www.MedChemE/Targets/In

2、doleamine 2,3-Dioxygenase (IDO).html HYPERLINK https:/www.MedChemE/Targets/Indoleamine 2,3-Dioxygenase (IDO).html (IDO)Indoleamine 2, 3-dioxygenase (IDO) is an inflammatory cytokine-inducible rate-limiting enzyme of the tryptophan (Trp) catabolism,which is involved in the inhibition of intracellular

3、 pathogen replication as well as in immunomodulation. To date, three types oftryptophan-metabolizing enzymes have been identified: IDO1, IDO2 and tryptophan 2,3-dioxygenase 2.IDO is an intracellular enzyme that is constitutively expressed in several human and mouse cells. Being present in innate imm

4、unecells, such as Mos and dendritic cells (DCs), IDO catalyzes the initial rate-limiting step of tryptophan (Trp) catabolism, thus leadingto the production of immunoregulatory catabolites (collectively known as kynurenines).The IDO gene promoter contains multiple sequence elements that confer respon

5、siveness to proinflammatory mediators, therebydemonstrating the strong correlation between inflammation and induced IDO expression.www.MedChemE 1 HYPERLINK https:/www.MedChemE/Targets/Indoleamine 2,3-Dioxygenase (IDO).html Indoleamine HYPERLINK https:/www.MedChemE/Targets/Indoleamine 2,3-Dioxygenase

6、 (IDO).html HYPERLINK https:/www.MedChemE/Targets/Indoleamine 2,3-Dioxygenase (IDO).html 2,3-Dioxygenase HYPERLINK https:/www.MedChemE/Targets/Indoleamine 2,3-Dioxygenase (IDO).html HYPERLINK https:/www.MedChemE/Targets/Indoleamine 2,3-Dioxygenase (IDO).html (IDO) HYPERLINK https:/www.MedChemE/Targe

7、ts/Indoleamine 2,3-Dioxygenase (IDO).html HYPERLINK https:/www.MedChemE/Targets/Indoleamine 2,3-Dioxygenase (IDO).html Inhibitors HYPERLINK https:/www.MedChemE/rac-ido1-in-5.html (Rac)-IDO1-IN-5Cat. No.: HY-111540A HYPERLINK https:/www.MedChemE/rac-indoximod.html (Rac)-Indoximod(1-Methyl-DL-tryptoph

8、an; (Rac)-NLG-8189) Cat. No.: HY-133897(Rac)-IDO1-IN-5 (Example 1) is a racemate ofIDO1-IN-5. IDO1-IN-5 is a potent, selective andbrain penetrated inhibitor of Indoleamine2,3-Dioxygenase 1 (IDO1) activity, binds toapo-IDO1 lacking heme rather than matureheme-bound IDO1.(Rac)-Indoximod (1-Methyl-DL-t

9、ryptophan) is anindoleamine 2,3-dioxygenase (IDO) inhibitor.Purity: 99.12%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 98.13%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 50 mg HYPERLINK https:/www.MedChemE/s-ido1-in-5.html (S)-IDO1-IN-5C

10、at. No.: HY-111540B HYPERLINK https:/www.MedChemE/s-indoximod.html (S)-Indoximod(1-Methyl-L-tryptophan; (S)-NLG-8189) Cat. No.: HY-N0707(S)-IDO1-IN-5 (Example 1B) is an active S-isomerof IDO1-IN-5. (S)-IDO1-IN-5 binds to IDOL with anIC value less than 1.5 .50(S)-Indoximod (1-Methyl-L-tryptophan) is

11、aninhibitor of indoleamine 2,3-dioxygenase (IDO).(S)-Indoximod can be used for the research ofcancer.Purity: 99.19%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 99.03%Clinical Data: No Development ReportedSize: 100 mg HYPERLINK https:/www.MedChemE/s-indoximod-d

12、3.html (S)-Indoximod-d3(1-Methyl-L-tryptophan-d3; (S)-NLG-8189-d3) Cat. No.: HY-N0707S HYPERLINK https:/www.MedChemE/bms-986242.html BMS-986242Cat. No.: HY-139204(S)-Indoximod-d3 is the deuterium labeled(S)-Indoximod. (S)-Indoximod(1-Methyl-L-tryptophan) is an inhibitor ofindoleamine 2,3-dioxygenase

13、 (IDO). (S)-Indoximodcan be used for the research of cancer.BMS-986242 is an orally active, potent andselective indoleamine-2,3-dioxygenase 1 (IDO1)inhibitor. BMS-986242 can be used for the researchof cancer.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.42%Clinical Data

14、: No Development ReportedSize: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/bmt-297376.html BMT-297376 HYPERLINK https:/www.MedChemE/bmt-297376.html HYPERLINK https:/www.MedChemE/Coptisine.html CoptisineCat. No.: HY-139205(Coptisin) Cat. No.: HY-N0430BMT-297376, the optimized Linr

15、odostat, is a potentIDO1 inhibitor.Coptisine is an alkaloid from Chinese goldthread,and acts as an efficient uncompetitive IDOinhibitor with a K value of 5.8 M and ani IC50value of 6.3 M.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development Reporte

16、dSize: 5 mg, 10 mg, 25 mg HYPERLINK https:/www.MedChemE/Coptisine-chloride.html Coptisine HYPERLINK https:/www.MedChemE/Coptisine-chloride.html HYPERLINK https:/www.MedChemE/Coptisine-chloride.html chloride HYPERLINK https:/www.MedChemE/Coptisine-chloride.html HYPERLINK https:/www.MedChemE/coptisine

17、-sulfate.html Coptisine HYPERLINK https:/www.MedChemE/coptisine-sulfate.html HYPERLINK https:/www.MedChemE/coptisine-sulfate.html SulfateCat. No.: HY-N0736 Cat. No.: HY-N0430ACoptisine chloride is an alkaloid from Chinesegoldthread, and acts as an efficient uncompetitiveIDO Kinhibitor with a i value

18、 of 5.8 M and an IC50value of 6.3 M.Coptisine Sulfate is an alkaloid from Chinesegoldthread, and acts as an efficient uncompetitiveIDO inhibitor with a Ki value of 5.8 M and an IC50value of 6.3 M.Purity: 98.24%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mgPurity:

19、98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/INCB-024360.html Epacadostat(INCB 024360) Cat. No.: HY-15689 HYPERLINK https:/www.MedChemE/8-Nitrotryptanthrin.html GNF-PF-3777(8-Nitrotryptanthri

20、n) Cat. No.: HY-100687Epacadostat (INCB 024360) is a potent andselective indoleamine 2,3-dioxigenase 1 (IDO1)inhibitor with an IC of 71.8 nM.50GNF-PF-3777 (8-Nitrotryptanthrin) is a potenthuman indoleamine 2,3-dioxygenase 2 (hIDO2)inhibitor which significantly reduces IDO2activity with K of 0.97 M.i

21、Purity: 99.66%Clinical Data: Phase 3Size: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 98.56%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/hi5.html HI5Cat. No.: HY-146261 HYPERLINK https:/www.MedChemE/IDO/TDO_Inhibitor.

22、html IACS-8968(IDO/TDO Inhibitor) Cat. No.: HY-112164HI5 is a potent tublin and IDO inhibitor, with anIC value of 70 nM in HeLa cells. HI5 inhibit IDO50expression and decrease kynurenine production,leading to stimulating T cells activation andproliferation.IACS-8968 (IDO/TDO Inhibitor) is a dual IDO

23、 andTDO inhibitor, with pIC s of 6.43 for IDO and5098%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98.29%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg HYPERLINK https:/www.MedChemE/IDO/TDO_Inhibitor_R-enantiomer.html IACS-8968 HYPERLINK https:/www.MedChemE/IDO/TDO_In

24、hibitor_R-enantiomer.html HYPERLINK https:/www.MedChemE/IDO/TDO_Inhibitor_R-enantiomer.html R-enantiomer(IDO/TDO Inhibitor (R-enantiomer) Cat. No.: HY-112164A HYPERLINK https:/www.MedChemE/IDO/TDO_Inhibitor_S-enantiomer.html IACS-8968 HYPERLINK https:/www.MedChemE/IDO/TDO_Inhibitor_S-enantiomer.html

25、 HYPERLINK https:/www.MedChemE/IDO/TDO_Inhibitor_S-enantiomer.html S-enantiomer(IDO/TDO Inhibitor (S-enantiomer) Cat. No.: HY-112164BIACS-8968 (R-enantiomer) is the R-enantiomer ofIACS-8968. IACS-8968 is a dual IDO and TDOinhibitor, with pIC s of 6.43 for IDO and 550for TDO, respectively.IACS-8968 (

26、S-enantiomer) is the S-enantiomer ofIACS-8968. IACS-8968 is a dual IDO and TDOinhibitor, with pIC s of 6.43 for IDO and 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/IDO-IN-12.html IDO-IN-12 HYPERLINK https:/www.MedChemE/IDO-IN-12.html HYPERLINK https:/www.M

27、edChemE/ido-in-13.html IDO-IN-13Cat. No.: HY-115122 Cat. No.: HY-129749IDO-IN-12 is an indoleamine 2,3-dioxygenase (IDO)inhibitor extracted from patent WO 2017181849 A1.IDO-IN-13 is a potent indoleamine2,3-dioxygenase 1 (IDO1) inhibitor with an EC50of 17 nM, extracted from patent WO2019040102A1,exam

28、ple 43.Purity: 99.22%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgwww.MedChemE 3 HYPERLINK https:/www.MedChemE/ido-in-14.html IDO-IN-14 HYPERLINK https:/www.MedChemE/ido-in-14.html HYPERLINK https:/www.MedChemE/ido-in-1

29、5.html IDO-IN-15Cat. No.: HY-139653 Cat. No.: HY-139883IDO-IN-14 is an IDO inhibitor with an IC value of500.6928 nM.IDO-IN-15 is an IDO1 inhibitor (IC 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedCh

30、emE/ido-in-16.html IDO-IN-16 HYPERLINK https:/www.MedChemE/ido-in-16.html HYPERLINK https:/www.MedChemE/IDO-IN-3.html IDO-IN-3Cat. No.: HY-142933 Cat. No.: HY-16987IDO-IN-16 (compound 5) is an IDO inhibitor, with anIC of 36 nM.50IDO-IN-3 is a potent indoleamine 2,3-dioxygenase(IDO) inhibitor with an

31、 IC of 290 nM.50Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.88%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 2 mg, 5 mg, 10 mg, 50 mg HYPERLINK https:/www.MedChemE/IDO-IN-4.html IDO-IN-4Cat. No.: HY-18769 HYPERLINK https:/www.MedChemE/IDO-IN-5.html IDO-IN-5(

32、NLG-1489) Cat. No.: HY-18770IDO-IN-4 is an indoleamine 2,3-dioxygenase 1(IDO-1) inhibitor, extracted from patentWO2014150677A1, Compound example 1 enantiomer 1.IDO-IN-5 (NLG-1489) is an indoleamine2,3-dioxygenase (IDO) inhibitor extracted frompatent WO WO2012142237A1, compound 1489, has anIC of 1-10

33、 M.50Purity: 99.40%Clinical Data: No Development ReportedSize: 2 mg, 5 mg, 10 mg, 50 mgPurity: 95.16%Clinical Data: No Development ReportedSize: 5 mg, 10 mg HYPERLINK https:/www.MedChemE/IDO-IN-6.html IDO-IN-6 HYPERLINK https:/www.MedChemE/IDO-IN-6.html HYPERLINK https:/www.MedChemE/NLG919.html IDO-

34、IN-7(NLG-1486) Cat. No.: HY-18770A (NLG-919 analogue; GDC-0919 analogue) Cat. No.: HY-13983IDO-IN-6 (NLG-1486) is an indoleamine2,3-dioxygenase (IDO) inhibitor extracted frompatent WO WO2012142237A1, Compound 1486, has anIC of 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg4 Tel: 609-228-6

35、898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/ido-tdo-in-1.html IDO/TDO-IN-1 HYPERLINK https:/www.MedChemE/ido-tdo-in-1.html HYPERLINK https:/www.MedChemE/IDO1_and_HDAC1_Inhibitor.html IDO1 HYPERLINK https:/www.MedChemE/IDO1_and_HDAC1_Inhibitor.html HYPERLINK https:/www.Me

36、dChemE/IDO1_and_HDAC1_Inhibitor.html and HYPERLINK https:/www.MedChemE/IDO1_and_HDAC1_Inhibitor.html HYPERLINK https:/www.MedChemE/IDO1_and_HDAC1_Inhibitor.html HDAC1 HYPERLINK https:/www.MedChemE/IDO1_and_HDAC1_Inhibitor.html HYPERLINK https:/www.MedChemE/IDO1_and_HDAC1_Inhibitor.html InhibitorCat.

37、 No.: HY-128355 Cat. No.: HY-112147IDO/TDO-IN-1 (compound 25) is a highly potent andorally active dual indoleamine-2,3-dioxygenase(IDO) and tryptophan 2,3-dioxygenase (TDO)inhibitor with IC s of 9.7 and 47 nM,50respectively .IDO1 and HDAC1 Inhibitor (Compound 10) is a dualIDO1 and HDAC1 inhibitor wi

38、th IC s of 69.0 nM and5066.5 nM, respectively.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/ido1-in-11.html IDO1-IN-11 HYPERLINK https:/www.MedChemE/ido1-in-11.html HYPERLINK https:/www

39、.MedChemE/ido1-in-12.html IDO1-IN-12Cat. No.: HY-145332 Cat. No.: HY-145355IDO1-IN-11 is an IDO1 inhibitor with an IC value50of 0.6 nM.IDO1-IN-12 is a potent and orally available IDO1inhibitor.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development R

40、eportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/ido1-in-13.html IDO1-IN-13 HYPERLINK https:/www.MedChemE/ido1-in-13.html HYPERLINK https:/www.MedChemE/ido1-in-14.html IDO1-IN-14Cat. No.: HY-144273 Cat. No.: HY-144274IDO1-IN-13 (compound 27a) is a potent IDO1inhibitor with an IC of 61.6 nM. IDO

41、1-IN-13 has50cellular IDO1 inhibition (HeLa EC = 30 nM).50IDO1-IN-13 decreases 51% of the kyn/trp ratio inSK-OV-3 xenograft tumor tissues.IDO1-IN-14 (compound 4a) is a potent IDO1 inhibitorwith an IC of 396.9 nM. IDO1-IN-14 has cellular50IDO1 inhibition (HeLa EC =3393 nM).50Purity: 98%Clinical Data:

42、 No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/ido1-in-15.html IDO1-IN-15 HYPERLINK https:/www.MedChemE/ido1-in-15.html HYPERLINK https:/www.MedChemE/ido1-in-16.html IDO1-IN-16Cat. No.: HY-144465 Cat. No.: HY-14

43、4466IDO1-IN-15 is a potent IDO1 inhibitor (IC =12750nM). IDO1-IN-15 has comparable potency againstIDO1 enzyme in vitro with Epacadostat.IDO1-IN-16 (I-1) is an IDO1 inhibitor targetingholo-IDO1, with an IC of 127 nM.50Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinica

44、l Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/ido1-in-17.html IDO1-IN-17 HYPERLINK https:/www.MedChemE/ido1-in-17.html HYPERLINK https:/www.MedChemE/ido1-in-2.html IDO1-IN-2Cat. No.: HY-144468 Cat. No.: HY-130607IDO1-IN-17 (I-4) is an IDO1 inhibitor, with an IC50of 0.

45、44 M in hela cells.IDO1-IN-2 (compound 16) is a potent and selectiveIDO1 inhibitor with IC s of 81 nM, 59 nM (mouse)50and 28 nM (rat), respectively. IDO1-IN-2 hasanti-cancer activity.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSiz

46、e: 1 mg, 5 mgwww.MedChemE 5 HYPERLINK https:/www.MedChemE/ido1-in-20.html IDO1-IN-20 HYPERLINK https:/www.MedChemE/ido1-in-20.html HYPERLINK https:/www.MedChemE/LY-3381916.html IDO1-IN-5Cat. No.: HY-146215 Cat. No.: HY-111540Hy-146215 is an enzyme that catalyzes theoxidative metabolism of tryptophan

47、. It canimmunosuppress tumors in the tumormicroenvironment.IDO1-IN-5 is a potent, selective and brainpenetrated inhibitor of IDO1 activity, binds toapo-IDO1 lacking heme rather than matureheme-bound IDO1.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98.58%Clinical Data: No

48、 Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/ido1-in-7.html IDO1-IN-7 HYPERLINK https:/www.MedChemE/ido1-in-7.html HYPERLINK https:/www.MedChemE/ido1-2-in-1.html IDO1/2-IN-1Cat. No.: HY-134583 Cat. No.: HY-145280IDO1-IN-7 is a highly potent a

49、nd selectiveindoleamine-2,3-dioxygenase-1 (IDO1) inhibitor,with an IC of 6.1 nM in in the cellular assay50(SKOV3). IDO1-IN-7 has immunomodulatory effects.IDO1-IN-7 can be used for the research of cancer.IDO1/2-IN-1 (compound 4t) is the first potentIDO1/IDO2 dual inhibitor with IC s of 28 nM and50144

50、 nM for IDO1 and IDO2, respectively.IDO1/2-IN-1 exhibits antitumor activies. Orallyactive.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/ido1-tdo-in-1.html IDO1/TDO-IN-1 HYPERLINK https:

51、/www.MedChemE/ido1-tdo-in-1.html HYPERLINK https:/www.MedChemE/IDO5L.html IDO5LCat. No.: HY-144778 Cat. No.: HY-15683IDO1/TDO-IN-1 (30) is a potent dual IDO1(uncompetitive, Ki of 0.23 M) and TDO(competitive, K of 0.73 M) inhibitor.iIDO1/TDO-IN-1 (30) significantly promotes cellapoptosis through the

52、potentialmitochondria-mediated Bcl-2/Bax pathway.IDO5L is a potent indoleamine 2,3-dioxygenase (IDO)inhibitor with an IC of 67 nM.50Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.89%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 10 mg, 50 mg, 100 mg, 500 mg, 1 g

53、 HYPERLINK https:/www.MedChemE/Indoximod.html Indoximod HYPERLINK https:/www.MedChemE/Indoximod.html HYPERLINK https:/www.MedChemE/kushenol-e.html Kushenol HYPERLINK https:/www.MedChemE/kushenol-e.html HYPERLINK https:/www.MedChemE/kushenol-e.html E(1-Methyl-D-tryptophan; NLG-8189) Cat. No.: HY-1672

54、4Cat. No.: HY-N2463Indoximod (1-Methyl-D-tryptophan) is an orallyactive indoleamine 2,3-dioxygenase (IDO) pathwayinhibitor. Indoximod acts as a Trp mimetic inregulating mTOR. Indoximod is an immunometabolicadjuvant used for the research of cancer.Kushenol E is a class of flavonoids isolated fromSoph

55、ora flavescens and is a non-competitiveindoleamine 2,3-dioxygenase 1 (IDO1) inhibitorwith an IC50 of 7.7M and a Ki of 9.5M, hasanti-tumor activity.Purity: 99.39%Clinical Data: Phase 2Size: 250 mgPurity: 96.0%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/BMS-986

56、205.html Linrodostat HYPERLINK https:/www.MedChemE/BMS-986205.html HYPERLINK https:/www.MedChemE/Navoximod.html Navoximod(BMS-986205; ONO-7701) Cat. No.: HY-101560 (GDC-0919; NLG-919) Cat. No.: HY-18770BLinrodostat (BMS-986205) is a selective andirreversible indoleamine 2,3-dioxygenase 1(IDO1) inhib

57、itor with an IC value of 1.1 nM in50IDO1-HEK293 cells. Linrodostat is well toleratedwith potent pharmacodynamic activity in advancedcancers.Navoximod (GDC-0919; NLG-919) is a potent IDO(indoleamine-(2,3)-dioxygenase) pathway inhibitorwith K/ of 7 nM/75 nM.i EC50Purity: 99.89%Clinical Data: Phase 3Si

58、ze: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mgPurity: 99.99%Clinical Data: Phase 1Size: 10 mM 1 mL, 1 mg, 5 mg, 10 mg6 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/Necrostatin-1.html Necrostatin-1(Nec-1) Cat. No.: HY-15760 HYPERLINK https:/www.Med

59、ChemE/nlg802.html NLG802Cat. No.: HY-145346Necrostatin-1 (Nec-1) is a potent necroptosisinhibitor with an EC of 490 nM in Jurkat50cells. Necrostatin-1 inhibits RIP1 kinase(EC50=182 nM). Necrostatin-1 is also an IDOinhibitor.NLG802 is a prodrug of indoximod, an orally activeindoleamine 2,3-dioxygenas

60、e (IDO) inhibitor.Purity: 99.87%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 10 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/palmatine.html Palmatine HYPERLINK https:/www.MedChemE/palmatine.html HYPERLINK https:/www.MedCh