Gap-Junction-Protein-Inhibitors-Modulators-MCE

1、 HYPERLINK https:/www.MedChemE/Targets/Gap Junction Protein.html Gap HYPERLINK https:/www.MedChemE/Targets/Gap Junction Protein.html HYPERLINK https:/www.MedChemE/Targets/Gap Junction Protein.html Junction HYPERLINK https:/www.MedChemE/Targets/Gap Junction Protein.html HYPERLINK https:/www.MedChemE/

2、Targets/Gap Junction Protein.html ProteinGap junction (GJ) channels span the plasma membranes of adjacent cells and are formed by the docking of two hemichannels(connexons) oligomerized from connexin (Cx) proteins, which consist of 21 distinct isoforms. GJs provide a direct pathway forcell-to-cell e

3、lectrical signaling and metabolic communication, allowing the passage of small ions, amino acids, metabolites,tetraethylammonium and signaling molecules such as cAMP, IP3, siRNA and small peptide.Gap junction channels provide the basis for intercellular communication in the cardiovascular system for

4、 maintenance of the normalcardiac rhythm, regulation of vascular tone and endothelial function as well as metabolic interchange between the cells. In theheart, GJs mediate electrical coupling between cardiac myocytes, forming the cell-to-cell pathways for orderly spread of the waveof electrical exci

5、tation responsible for synchronous contraction. Gap junctions also play an important role in the control of bladdercontractile response and in the regulation of various immune inflammatory processes.www.MedChemE 1 HYPERLINK https:/www.MedChemE/Targets/Gap Junction Protein.html Gap HYPERLINK https:/w

6、ww.MedChemE/Targets/Gap Junction Protein.html HYPERLINK https:/www.MedChemE/Targets/Gap Junction Protein.html Junction HYPERLINK https:/www.MedChemE/Targets/Gap Junction Protein.html HYPERLINK https:/www.MedChemE/Targets/Gap Junction Protein.html Protein HYPERLINK https:/www.MedChemE/Targets/Gap Jun

7、ction Protein.html HYPERLINK https:/www.MedChemE/Targets/Gap Junction Protein.html Inhibitors HYPERLINK https:/www.MedChemE/Targets/Gap Junction Protein.html HYPERLINK https:/www.MedChemE/Targets/Gap Junction Protein.html & HYPERLINK https:/www.MedChemE/Targets/Gap Junction Protein.html HYPERLINK ht

8、tps:/www.MedChemE/Targets/Gap Junction Protein.html Modulators HYPERLINK https:/www.MedChemE/AT-1002.html AT-1002 HYPERLINK https:/www.MedChemE/AT-1002.html HYPERLINK https:/www.MedChemE/AT-1002_TFA.html AT-1002 HYPERLINK https:/www.MedChemE/AT-1002_TFA.html HYPERLINK https:/www.MedChemE/AT-1002_TFA

9、.html TFACat. No.: HY-114426 Cat. No.: HY-114426AAT-1002, a 6-mer synthetic peptide, is a tightjunction regulator and absorption enhancer.AT-1002 TFA, a 6-mer synthetic peptide, is a tightjunction regulator and absorption enhancer.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPuri

10、ty: 99.72%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/carbenoxolone-disodium.html Carbenoxolone HYPERLINK https:/www.MedChemE/carbenoxolone-disodium.html HYPERLINK https:/www.MedChemE/carbenoxolone-disodium.html disodiumCat. No.: H

11、Y-B1367 HYPERLINK https:/www.MedChemE/gap-134.html Danegaptide(GAP-134; ZP 1609) Cat. No.: HY-10913Carbenoxolone disodium is the active metaboliteof Glycyrrhizic acid (HY-N0184) and the inhibitorof human 11-HSD and bacterial 3, 20-HSD.Carbenoxolone disodium is an uncoupling agent forgap junctions an

12、d a potent inhibitor of Vacciniavirus replication.Danegaptide (GAP-134) is a potent, selective andorally active gap-junction modifier with anantiarrhythmic effect.Purity: 99.88%Clinical Data: LaunchedSize: 10 mM 1 mL, 25 mg, 50 mg, 100 mgPurity: 98%Clinical Data: Phase 2Size: 1 mg, 5 mg HYPERLINK ht

13、tps:/www.MedChemE/GAP-134-Hydrochloride.html Danegaptide HYPERLINK https:/www.MedChemE/GAP-134-Hydrochloride.html HYPERLINK https:/www.MedChemE/GAP-134-Hydrochloride.html Hydrochloride(GAP-134 Hydrochloride; ZP 1609 Hydrochloride) Cat. No.: HY-10913A HYPERLINK https:/www.MedChemE/Gap_26.html Gap HYP

14、ERLINK https:/www.MedChemE/Gap_26.html HYPERLINK https:/www.MedChemE/Gap_26.html 26Cat. No.: HY-P1082Danegaptide Hydrochloride (GAP-134 Hydrochloride)is a potent, selective and orally activegap-junction modifier with an antiarrhythmiceffect.Gap 26 is a connexin mimetic peptide, composed ofresidue nu

15、mbers 63-75 of the first extracellularloop of connexin 43 (gap junction blocker),containing the SHVR amino acid motif.Purity: 99.75%Clinical Data: Phase 2Size: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 99.64%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg HYPERLINK https:/ww

16、w.MedChemE/gap-26-tfa.html Gap HYPERLINK https:/www.MedChemE/gap-26-tfa.html HYPERLINK https:/www.MedChemE/gap-26-tfa.html 26 HYPERLINK https:/www.MedChemE/gap-26-tfa.html HYPERLINK https:/www.MedChemE/gap-26-tfa.html TFA HYPERLINK https:/www.MedChemE/gap-26-tfa.html HYPERLINK https:/www.MedChemE/Ga

17、p_27.html Gap HYPERLINK https:/www.MedChemE/Gap_27.html HYPERLINK https:/www.MedChemE/Gap_27.html 27Cat. No.: HY-P1082A Cat. No.: HY-P0139Gap 26 TFA is a connexin mimetic peptide, composedof residue numbers 63-75 of the firstextracellular loop of connexin 43 (gap junctionblocker), containing the SHV

18、R amino acid motif.Gap 27, a synthetic connexin43 mimetic peptide, isa gap junction inhibitor. Gap 27 possessesconserved sequence homology to a portion of thesecond extracellular loop leading into the fourthtransmembrane connexin segment.Purity: 99.03%Clinical Data: No Development ReportedSize: 1 mg

19、, 5 mg, 10 mgPurity: 98.07%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/gap19.html Gap19 HYPERLINK https:/www.MedChemE/gap19.html HYPERLINK https:/www.MedChemE/gap19-tfa.html Gap19 HYPERLINK https:/www.MedChemE/gap19-tfa.html HYPERLINK https:/www.MedChemE/gap1

20、9-tfa.html TFACat. No.: HY-P1136 Cat. No.: HY-P1136AGap19, a peptide derived from nine amino acids ofthe Cx43 cytoplasmic loop (CL), is a potent andselective connexin 43 (Cx43) hemichannelblocker. Gap19 inhibits hemichannels caused bypreventing intramolecular interactions of theC-terminus (CT) with

21、the CL.Gap19 TFA, a peptide derived from nine amino acidsof the Cx43 cytoplasmic loop (CL), is a potent andselective connexin 43 (Cx43) hemichannelblocker. Gap19 TFA inhibits hemichannels caused bypreventing intramolecular interactions of theC-terminus (CT) with the CL.Purity: 98%Clinical Data: No D

22、evelopment ReportedSize: 1 mg, 5 mgPurity: 95.11%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/Larazotide_acetate.html Larazotide HYPERLINK https:/www.MedChemE/Larazotide_acetate.html HYPERLINK ht

23、tps:/www.MedChemE/Larazotide_acetate.html acetateCat. No.: HY-106268A HYPERLINK https:/www.MedChemE/meclofenamic-acid.html Meclofenamic HYPERLINK https:/www.MedChemE/meclofenamic-acid.html HYPERLINK https:/www.MedChemE/meclofenamic-acid.html acid(Meclofenamate) Cat. No.: HY-117275Larazotide acetate

24、is a synthetic peptide.Larazotide acetate acts as a tight junctionregulator and reverses leaky junctions to theirnormally closed state.Meclofenamic Acid (Meclofenamate), anon-steroidal, anti-inflammatory agent, is ahighly selective fat mass and obesity-associated(FTO) enzyme inhibitor. Meclofenamic

25、Acidcompetes with FTO binding for the m(6)A-containingnucleic acid.Purity: 99.68%Clinical Data: Phase 3Size: 10 mM 1 mL, 1 mg, 5 mg, 10 mg, 25 mgPurity: 98%Clinical Data: LaunchedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/meclofenamate-sodium.html Meclofenamic HYPERLINK https:/www.MedChemE/meclo

26、fenamate-sodium.html HYPERLINK https:/www.MedChemE/meclofenamate-sodium.html acid HYPERLINK https:/www.MedChemE/meclofenamate-sodium.html HYPERLINK https:/www.MedChemE/meclofenamate-sodium.html sodium(Meclofenamate sodium) Cat. No.: HY-B1320 HYPERLINK https:/www.MedChemE/meclofenamic-acid-d4.html Me

27、clofenamic HYPERLINK https:/www.MedChemE/meclofenamic-acid-d4.html HYPERLINK https:/www.MedChemE/meclofenamic-acid-d4.html acid-d4(Meclofenamate-d4) Cat. No.: HY-117275SMeclofenamic acid (Meclofenamate) sodium is anonsteroidal anti-inflammatory drug (NSAID)approved for use in arthritis (osteo andrhe

28、umatoid), analgesia (mild to moderate pain),dysmenorrhea, and heavy menstrual blood loss(menorrhagia).Meclofenamic acid-d4 (Meclofenamate-d4) is thedeuterium labeled Meclofenamic acid. MeclofenamicAcid (Meclofenamate), a non-steroidal,anti-inflammatory agent, is a highly selectivefat mass and obesit

29、y-associated (FTO) enzymeinhibitor.Purity: 99.86%Clinical Data: LaunchedSize: 10 mM 1 mL, 50 mg, 100 mg, 200 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 10 mg HYPERLINK https:/www.MedChemE/peptide5.html Peptide5Cat. No.: HY-P2275 HYPERLINK https:/www.MedChemE/rotigaptide.html Roti

30、gaptide(ZP123) Cat. No.: HY-106225Peptide5, a connexin 43 mimetic peptide, reduceanimals swelling, astrogliosis, and neuronal celldeath after spinal cord injury.Rotigaptide (ZP123) is a novel and specificmodulator of connexin 43 (Cx43). Rotigaptideprevents the uncoupling of Cx43-mediated gapjunction

31、 communication and normalizes cell-to-cellcommunication during acute metabolic stress.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.63%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 1 mg, 5 mg HYPERLINK https:/www.MedChemE/tat-gap19.html TAT-Gap19 HYPERLINK https:/www.MedChemE/tat-gap19.html HYPERLINK https:/www.MedChemE/tat-gap19-tfa.htm