介孔论文：介孔无机抗菌材料的制备及在棉织物上的应用

1、 介孔论文：介孔无机抗菌材料的制备及在棉织物上的应用【中文摘要】由于无机抗菌剂广谱抗菌,抗药性小,安全性高,耐热性好而且杀菌效果持久等优点从20世纪80年代开始迅猛发展,迅速引起了人们的关注。在所有金属中,银可以广泛应用于催化,电学和光学领域,除此之外银还是一种具有广谱杀菌作用的材料,其杀菌原理与抗生素的有机抗菌不同,属于一种无机抗菌,而且让病菌无法产生抗药性。有序介孔氧化硅材料SBA-15具有巨大的比表面积和孔容,以及无毒、生物兼容性等特点,同其他普通缓释药物制剂相比,其有更大的药物负载量和更好的缓释效果,因此它被作为新型药物控缓释载体材料的研究越来越受到重视,并且取得了令人瞩进展。SBA-

2、15孔径分布狭窄,孔道结构规则,其内表面存在活性基团,易于被修饰,非常有利于引入其他分子。这些固有的特征使它与其他无机载体相比,表现出对银离子更好的吸附性能。另外介孔材料的多孔结构,尤其是大于细菌尺度的孔道可以增大细菌与抗菌剂之间的接触概率,提高抗菌剂的杀菌效率,因此其在载银抗菌剂的研制上具有广阔的前景。本论文采用溶胶凝胶法,以三嵌段共聚物P123作为结构导向剂,正硅酸乙酯为硅源,制备出有序介孔氧化硅SBA-15,然后用硅烷偶联剂APTES对其进行表面改性,通过共价嫁接将带有机官能团的硅烷以共价键的形式结合在介孔材料的内表面,在温和条件下制备出性能良好的金属离子型无机抗菌材料,并研究了不同条件

3、对载银量的影响。最后优选分散剂和粘合剂,采用浸渍的整理工艺将制备的无机抗菌剂成功用于棉织物的抗菌整理,同时进行防变色整理,并对抗菌棉织物的抗菌性能及机械性能进行测试。本文的研究内容和结论如下:（1）实验制备的SBA-15具有高度有序二维六方孔道结构,且孔径分布单一,较大的比表面积和较大的孔容,样品的比表面积采用BET法计算可以达到611m2/g,孔容为0.65cm3/g。孔道长程有序,有利于提高介孔材料药物装载的能力。（2）采用APTES对SBA-15进行了表面改性。硅烷偶联剂通过化学键的形式嫁接到介孔材料上,维持了孔道原有的长程有序结构和良好的热稳定性。（3）采用单因素分析,探讨了AgNO3

4、溶液浓度、载银时间、载银温度对SBA-15载银量的关系。（4）优选施加固着技术,对棉织物进行抗菌和防变色整理,赋予其抗菌功能。（5）经抗菌实验表明:棉织物经过添加量为1.00%的无机抗菌剂整理后,与大肠杆菌、金黄色葡萄球菌接触1小时,杀菌率均达到100%上。抗菌棉织物除具有良好的抗菌效果外,同时还有较好的耐水洗性,经过20次水洗后抗菌率大于95%。【英文摘要】Inorganic antibacterial agents with good properties of long lasting, stability, safe and broad-spectrum antibiosis, ove

5、rcome the drawbacks of organic antibacterial agents, and with excellent antibacterial activity against both bacteria and funguses, having attracted many researchersinterest in the field of antimicrobials since 1980s. In all metals, silver has widely applied in many fields for its advantages in catal

6、ytic, electronic and optical, otherwise, silver is good at broad-spectrum antibiosis. The principal inorganic antibacterial agents have been originated from metal ions, it will not lead up to drug resistance.Mesoporous silicas present high superficial areas and large uniform pores, non-toxic and bio

7、logical compatibility.The property of drug loading and controlled release is much better, compared with other carriers.Their silica wall surface can be modified with organic groups to adjusted their properties and achieve specific purposes. These inherent characteristics make the adsorption performa

8、nce to silver ions of mesoporous silica much better than other inorganic carrier. The structure of mesoporous material, especially for the pores, which is bigger than the bacteria, can increase the chance of contacts with antibacterial agent and bacteria, improving the antibacterial efficiency and m

9、ake the silver antibacterial agent an increasingly wide utilization in all fields.Mesoporous molecular sieves SBA-15 was synthesized by sol-gel process using tri-block copolymer P123 as a template agent and TEOS as silicon source in this paper. APTES (3-aminopropyl-triethoxysilane) was grafted on th

10、e surface of the SBA-15. Then the antibacterial agent was obtained at moderate condition. Finally, the cotton fabric was finished by the synthesized compound antibacterial agent through one time dipping. Besides,the problem of Ag type antibacterial agent tamishing has been resolved. The effect on th

11、e antibacterial property of the antibacterial fabrics was also tested.The main conclusions are as follows: (1) The prepared SBA-15 had the structure of two dimensional mesoporous with highly ordered hexagonal phase. The size distribution of mesoporous pore was verynarrow and uniform, the specific su

12、rface area of SBA-15 was 611m2/g, the pore volume of mesoporous pore was 0.65cm3/g. Highly ordered structure did benefit to the improvement of drug loading.(2) The surface of SBA-15 was modified by APTES. The amino groups were grafted on the surface of channels, the ordered structure and thermal abi

13、lity remained.(3) The relationship between initial concentration of silver nitrate, loading time, temperature and the amount of loaded silver was studied.(4) Optimal design on finishing was chosen to give the cotton fabric functional finish, which made the fabric antibacterial. Besides, the problem

14、of Ag type antibacterial agent tarnishing has been resolved.(5) The antibacterial test showed that this powder had 100% bacterial action on E.coli, S.aures and C.albicans within 1h by adding 1.00wt% antimicrobial on the fabrics. Antibacterial fabric are excellently antibiotic against the bacteria me

15、ntioned above and fairly wash fast.After washed ten times , the antibacterial rate of the antibacterial agent remained above 95%.【关键词】介孔 SBA-15 改性 载银 抗菌【备注】索购全文在线加好友：1.3.9.9.3.8848 同时提供论文写作一对一指导和论文发表委托服务【英文关键词】mesoporous SBA-15 modification silver loading antibacterial【目录】介孔无机抗菌材料的制备及在棉织物上的应用摘要4-6Ab

16、stract6-7第一章 绪论10-191.1 抗菌剂的定义及分类10-121.1.1 天然抗菌剂10-111.1.2 有机抗菌剂111.1.3 无机抗菌剂11-121.2 银系无机抗菌剂的杀菌机理12-141.2.1 银离子接触杀菌机理131.2.2 催化反应杀菌机理13-141.3 载银无机抗菌剂的制备技术14-161.3.1 离子交换法14-161.3.2 溶胶凝胶法161.3.3 有机/无机复配法161.4 载银无机抗菌剂在棉织物上的应用16-171.5 国内外载银无机抗菌剂的现状及发展趋势171.6 本论文研究目的意义及主要研究内容17-19第二章 抗菌剂载体的制备与表征19-332

17、.1 引言19-202.2 SBA-15 的制备20-262.2.1 溶胶凝胶法制备SBA-15 的机理20-212.2.2 实验过程21-222.2.3 结果与讨论22-262.3 SBA-15 的改性26-322.3.1 SBA-15 改性机理26-282.3.2 实验过程282.3.3 结果与讨论28-322.4 本章小结32-33第三章 抗菌剂的制备及表征33-403.1 引言333.2 载银量的测定33-343.3 实验部分34-353.3.1 实验试剂及仪器34-353.3.2 Ag/SBA-15 的制备353.4 结果与讨论35-393.4.1 不同浓度对载银量的影响35-363.4.2 不同载银时间对载银量的影响36-373.4.3 不同载银温度对载银量的影响37-383.4.4 EDS 分析383.4.5 XRD 分析38-393.4.6 TEM 分析393.5 本章小结39-40第四章 棉织物的抗菌整理40-494.1 引言404.2 抗菌剂的分散40-434.2.1 实验部分40-424.2.2 结果与讨论42-434.3 抗菌剂在棉织物上的粘合43-454.3.1 实验部分43-444.3.2 结果与讨论44-454.4 抗菌织物的防变色整理45-484.4.1 防变色机理45-46