动物来源的阳离子抗菌小肽

1、动物来源的阳离子抗菌小肽结构特点来源名称残基数成熟肽序列抗性富含脯氨酸Indoclicidin弱多聚-L-脯牛中性粒细Indoclicidin13ILPWKWPWWPWPR-amideB±apidaecin氨酸n型螺旋“非-a-螺胞蜜蜂淋巴液apiidaecin18GNNRPVYIPQPRPPHPRB一旋”非偏向多聚果蝇drosocin19LGKPRPYSPRPT*SHPRPIRV(*B一bactenecin-L-脯氨酸n型螺旋吸树虫蚕血淋巴蜜蜂淋巴液猪小肠Lebocin3abecinporcinePR-3920323439=O-GalAc-313GalVD-KGSYLPRPT*PP

2、RPIYNRN(*=O-GalAc)DLRFLYPRGKLPVPT*LPPFNPKPOIYIDMGNRY(*=O-GalAc)YVPLPNVPQPGRRFPTFPGQGPFNPKIKWPQGYRRRPRPPYLPRPRPPPFFPPRLPVVVB±多聚-L-脯氨牛中性粒细bactenecin542PRIPPGFPPRFPPRFP-amideRFRPPIRRPPIRPPFYPPFRPPIRPB,F酸n型螺旋结构未阐明，胞牛中性粒细bactenecin759PIFPPIRPPFRPPLRFPRRIRPRPPRLPRPRPRPLPF-PRGB一a-螺旋但较独特双性a-螺旋胞Styela-c

3、tavaclavaninC23PRPIPRPLPPRPGPRPRPVFHLLGKIIHHVGNFVYG-FSHB±,FClavanina-螺旋双性a-螺旋血细胞爪蟾皮肤爪蟾抗菌肽123VF-amideGIGKFLHSAGKFGKAFV-GEIB-,Fmagainincecropin双性a-螺旋Bombinavarigat皮肤Apismellifer毒液猪小肠bombininmellitincecropinP1272631MKSGIGGALLSAAKVGLKGL-AKGLAEHFNGIGALKVLTTGLPALISWIKRKRQQ-amideSWLSKTAKKLENSAKKRISEGI

4、不详B±B一andropinHyalophor-acecropiaSarcophagaperigrina幼虫血淋巴雄性果蝇cecropinAsarcotoxin1A雄性抗菌肽383934AIAIQGGPRKWK-LFKKIEKVGQNIRDGIIKAGPAVAVGQATQIAKGGWLKKIGKKIERVGQHTRDATIQGLGIAQQQAANVAATAR-amideVFIDILDKVENAIHNAAQVGIGB±B一B+(andropin)FAKPFEKLINPKhistatin-螺旋，抗真菌结构域人唾液histatinHRP-238DSHEKRHHGYRRKFHEKH

5、HSHREFPFYGDYGSNYLYDNB,FhistatinHRP-332DSHAKRHHGYKRKFHEKHHSHRGYRSNYLYDN不详3-折叠片层十二指肠肽1个一硫键牛中性粒细胞十二脂肠肽12RLCAIVVIRVCRB±3-折叠片层tachyplesin3-折叠,2个硫键Tachypleustridantatus血细胞白细胞TachyplesinI防御素I(polyphe-musin)1718KWCFRVCYRGICYRCR-amideRRWCFRVCYRGFCYRKCR-amideB±,FB±,Fprotegrin3-折叠,2个硫键猪白细胞proteg

6、rin117RGGRLCYCRRRCVCVGR-amideB±,Fa-螺旋及3-折叠，3个二硫键蝎子蜻蜓黑花蝇肉蝇蜂王浆甲虫幼虫蚊血淋巴lqhDef“防御素”黑花蝇素A(phormicin)sapecin皇室防御素rroyalisin)a.d防御素防御素A38384040514334GFGCPLKNQGACHRHCRSIRRRGGYCAGFFKQTCTCYRNGFGCPLKQMQCHRHCQTITGRSGGYCSGPLKLTCTCYRATCKLLSGTGINHSACAAHCLLRGNRGGYCNGKGVCVCRNATCKLLSGTGINHSACAAHCLLRGNRGGYCNGKAVC

7、VCRNVTCKLLSFKGQVNDSACAANCLSLGKAGGHCEKGVCICRKTSFKDLWDKYFVTCKLLSFEAKGFAANHSLCAAHCLAIGRRGGSCERGVCICRRATCKLLSGFGVGDSACAAHCIRGNRGGYCNSKKVCVCRN不详不详B+B+B+B+B-,与溶液协同3防御素3片层，3个硫键牛中性粒细胞牛气管上皮牛舌上皮人肾黏膜上皮鸡白细胞BNBD-12气管抗菌肽舌抗菌肽人3防御素-1gallinaciPLSCGRNGGVCIPIRCPVPMRQIGTCFGRPVKCCRSWNPVSCVRNKGICVPIRCPVPMRQI

8、GTCFGRPVKCCRSWQGVRNSQSCRRNGKICVPIR-CPGSMRQIGTCLGAQVKCCRRKKHYNCVSSGGQCYLSACPIFTKIQGTCYRGKAACCKGRKSDCFRKSGFCAFLKCPSLTLISGKCSRFYLCCKRIWB±,FB±,FB±,F不详B±a防御素3片层，3个硫键人白细胞防御素HNP-130ACYCRIPACIAGERRYGTCIYQGRLWAFCCB±,F兔白细胞防御素NP3A34GICACRRRFCPNSERFSGYCRVNGARYVRCCSRRB±,F小鼠Paneth细胞腺管素cryptdin,CRYPT-135LDRLVCYCRSRGCKGRERMNGTCRKGHLLYTLCCRB兔白细胞防御素RTNP132VTCYCRSTRCGFRE