医学免疫学英语试题资料讲解

1、医学免疫学英语试题精品文档I Choose one which is the best answer in each question(40 X1 point =40 )1. Immunological unresponsiveness to self antigens is called: ( A)A Tolerance B Tolerogen C Memory D Acquired immunity2. The signal transduction molecules associated with BCR are (B )A. CD21 and CD81. B. Ig and Ig &

2、#163;D79a,b C. IgD and IgM. D.ITAMs andITIMs.3. T cells are MHC-restricted in their ability to respond to antigen because (D )A. all antigen must be processed and presented to activate lymphocytes.B. during an infection, all cells in the body present antigen on MHC Class I.C. MHC binds antigen more

3、specifically than TCR does.D. TCR must recognize both antigen and MHC molecules.4. An antibody Fab contains ( A B)A. complementarity determining regions. B. H and L chain variable regions.C. one antigen binding region. D. one H-L interchain disulfide bond.5. Positive selection in the thymus is media

4、ted by: ( A )A Thymic epithelial cells. B Macrophages. C Dendritic cells. D B-cells.6. Type IV hypersentivity is often referred to as: ( B )A. Immediate hypersensitivity B. Delayed hypersensitivityC. Cytotoxic hypersensitivity D. Allergic hypersensitivity7. Type H hypersentivity is often referred to

5、 as: ( C )A. Immediate hypersensitivity B. Delayed hypersensitivityC. Cytotoxic hypersensitivity D. Allergic hypersensitivity8. Naive B cell expresses ( C )A. IgA alone B.IgA and IgG C IgM +IgD D.IgE and Ig9. T cell-derived cytokines ( D )A. are antigen-specific products of T cell activationB. are s

6、tored in the resting T cell and released on activationC. are MHC-restricted in their effectsD. influence the class of antibodies produced by B cell10. Neutrophils are attracted to an infected area by ( C )收集于网络,如有侵权请联系治理员删除精品文档A. IgM B. C1 C. C5a D. C811. Complement lyses cells by ( C )A. enzymatic

7、digestion of the cell membraneB. activation of adenylate cyclaseC. insertion of complement proteins into the cell membraneD. inhibition of elongation factor 212. CD8 is a marker of ( C)A. B cells B. Helper - T cells C. cytotoxic T cell D. M小13. MHC class H molecules are found on (B )A. Virtually all

8、 cells in the bodyB. B cells, DC and M 小C. Virtually all nucleated cells in the body D. Only on virally-infected cells.14. All of following cytokines are secreted by Th2 cells except (B )A. IL-4 B. IFN- T C. IL-5 D. IL-615. Which of the following is NOT true of CD4 + and CD8 + cell markers? ( D ) A.

9、 These are both surface glycoproteins expressed on T-cells.B. These serve to distinguish different types of T-cells, e.g., helper, suppressor and cytotoxic, from each other.C. These are not found associated with immunoglobulins.D. Both of the markers are present on ALL T-cells.16. Cells bearing MHC

10、class I plus peptide are targets for specific: ( B )A B-cells. B Cytotoxic T-cells. C Th1 cells. D Th2 cells.17. Dendritic cells are characterized by: ( D )A the presence of major basic protein B expression of CD3C expression of IgM molecules D their interface between the innate and adaptive immune

11、system18. Which of the following uniquely distinguishes the T-cell receptor (TCR) from an antibody? ( A )A. The TCR can bind an antigen fragment only in a trimolecular complex with either the class I or class II surface proteins of the major histocompatibility complexB. The TCR can function as a cel

12、l surface antigen receptor收集于网络,如有侵权请联系治理员删除精品文档C. The TCR is composed of two different types of polypeptide chainsD. The TCR is capable of participating in a cytotoxic reaction.19. A critical property of an antigen is ( A )A. Its ability to stimulate an immune responseB. a unique topological featur

13、e called an paratopeC. not a unique topological feature called an antigenic determinantD. the size of which is relatively small20.Opsonization of bacteria occurs through coating bacteria just with: ( A )A C3b B C8 C Membrane attack complex D IgM21. The following is characteristic of B- but not T-cel

14、ls: ( D )A Class I MHC. B CD3. C HIV virus receptor. D Surface immunoglobulin.22. . Which of the following molecules is expressed on the surface of matureCD4+T cells? ( C )A. B cell receptor B. CD1d C.CD3 D.CD823. . The thymus is the site of initial differentiation for ( D )A. B cells B. Erythrocyte

15、s C. Hematopietic stem cells D. T cells24. The membrane attack complex consists of: ( C )A OH B C3b3b,BbC C5b,6,7,8,9 D Properdin25. Type I hypersentivity is often referred to as: (A )A. Immediate hypersensitivity B. Delayed hypersensitivityC. Cytotoxic hypersensitivity D. Immune complex hypersensit

16、ivity26. Type m hypersentivity is often referred to as: ( D)A. Immediate hypersensitivity B. Delayed hypersensitivityC. Cytotoxic hypersensitivity D. Immune complex hypersensitivity27. The type I hypersentivity is mediated by: ( D )A. IgA B. IgD C. IgG D. IgE收集于网络,如有侵权请联系治理员删除精品文档28. The cytokine wh

17、ich is most involved in the class switch to IgE production is: ( D )A.IL-1 B.IL-2 C.TGF beta D.IL-429. Which type hypersensitivity is related to the mechanism of acute Arthus reaction: ( C )A. Type I hypersentivityB. TypeH hypersentivityC. Type m hypersentivityD. Type IV hypersentivity30. T-cell CD4

18、0L provides a costimulatory signal to B-cells by ligating: ( A )A CD40 B MHC class II C CD28 D CD1931. Which immunoglobulin can be transported through the placenta? ( A )A. IgG B. IgM C. Secretory IgA D. IgE32. Which immunoglobulin is the most one in the blood? ( A )A. IgG B. IgM C. Secretory IgA D.

19、 IgE33. Which immunoglobulin can mediate the immediate hypersensitivity? ( D )A. IgG B. IgM C. Secretory IgA D. IgE34. Molecules directly involved in NK cell mediated killing include: ( B )A nitric oxide B granzyme C complement D IFN- 丫35. Immune complexes consist of ( C )A. antibody plus complement

20、 B. basophil plus complementC. antigen plus antibody D. antigen plus complement36. The main costimulatory signal for activation of resting T-cells is provided by ligation of: ( A )A CD28 B Surface Ig C LFA-1 D VLA-437. The T-cell receptor antigen recognition signal is transduced by: ( E )A The TCR a

21、lpha chain. B The TCR beta chain. D CD2. E CD3.38. The T-cell ligand binding B7 on a professional antigen-presenting cell is: AA CD28 B CD2 C LFA-1 D ICAM-139. Secondary antibody responses are better because: ( C)收集于网络,如有侵权请联系治理员删除精品文档A They provide defense against unrelated antigensB The antibody c

22、an be made by both T and B cellsC They are stronger and fasterD They do not require T-cell help40. Which cell type produces antibodies?: ( D )A Macrophages B T-lymphocytes C NK D Plasma cellsII. Indicate whether each of the following statements is true or false.(10X2 points =20 )1. A hapten can stim

23、ulate antibody formation but cannot combine withantibody molecules. ( F)2. Booster shots are required because repeated exposure to an antigen buildsa stronger immune response. ( T)3. The Ig a /Ig 0 heterodimer and CD3 serve analogous functions in the Bcell receptor and T-cell receptor, respectively.

24、 ( T )4. Antigen-presenting cells express both class I and class II MHC molecules on their membranes. ( T )5. Babies can acquire IgE-mediated allergies by passive transfer of maternal antibody. ( F )6. Both CTLs and NK cells release perforin after interacting with target cells.(T )7. Target cell lys

25、is and destruction can be achieved by perforin released from antigen-specific cytotoxic T-cells ( T )8. The immune response is mediated via the humoral and/or cellular arms ofthe immune system ( T )9. Immediate type hypersensitivity is mediated by IgM. ( F )10. All cytokine-binding receptors cintain

26、 two or three subunits. ( T )m Answer the following questions in brief(10X4points =40 )收集于网络,如有侵权请联系治理员删除精品文档1. Name the three types of professional APCs, and give one example of nonprofessional APCs. B M DC endothelial cell2. Summarize the four major functions of complement system lysis of cells, bacteria and viruses opsonization to enhance phagocytosis clearance of immune complexes©stimulation of inflammation3. List the classical Cl