antipsychoticdrugs学习教案

1、会计学1antipsychoticdrugs第一页，共26页。disturbed perceptionsinappropriate emotions & action第1页/共26页第二页，共26页。第2页/共26页第三页，共26页。第3页/共26页第四页，共26页。第4页/共26页第五页，共26页。第5页/共26页第六页，共26页。 Phenothiazin 吩噻嗪类吩噻嗪类 chlorpromazine 氯丙嗪氯丙嗪 (wintermine 冬眠冬眠(dngmin)灵灵) 第6页/共26页第七页，共26页。 Blocking Mesolimbic system and mesoco

2、rtical D2-R More effective for treating positive symptom Substantia nigra- corpus striatum - extrapyramidal effects 锥体外系反应锥体外系反应(fnyng) Node-funnel - endocrine system action第7页/共26页第八页，共26页。mechanismsn decrease temperature no matter normal or high temperature n body temperature varies with the envir

3、onment第8页/共26页第九页，共26页。n autonomic NS effectsn blocking -Rn vasodilatationn “epinephrine reversal”n blocking M-R n atropine-like actionn endocrine system actionn increasing prolactin催乳素催乳素 secretionn inhibiting gonadotropic hormone促性腺激素，促性腺激素，n growth hormone生长激素生长激素(shn chn j s) secretion第9页/共26页第十

4、页，共26页。n chlorpromazine promethazine pethidinen（氯丙嗪（氯丙嗪 异丙嗪异丙嗪 哌哌替啶）替啶）第10页/共26页第十一页，共26页。(artane, )第11页/共26页第十二页，共26页。 tardive dyskinesia 迟发性运动障碍迟发性运动障碍 treated by antidopamine drugs (clozapine,氯氮平氯氮平)Neural antagonist severe symdromedrug-induced mind abnormality convulsion惊厥惊厥 and epilepsy癫痫癫痫alle

5、rgic reaction acute hypogranulocytosis (粒细胞减少粒细胞减少(jinsho)症症)cardiovascular and endocrine system reactionacute poisoning 急性中毒急性中毒第12页/共26页第十三页，共26页。du)uclozapine 氯氮平氯氮平第13页/共26页第十四页，共26页。第14页/共26页第十五页，共26页。Antimanic drugsnBipolar affective disorder （双极性情感障碍（双极性情感障碍(zhng i)）nCyclic manic attacks （往复性

6、躁狂发作）（往复性躁狂发作）nIn high spirit （情绪高涨）（情绪高涨）nOveractivity （过度活动）（过度活动）nParanoid thoughts （妄想）（妄想）第15页/共26页第十六页，共26页。Lithium Carbonate （碳酸锂）（碳酸锂）Clinical usen Based on the Li+ n treatment for bipolar disorder manic phase particularlyn prophylactic Li may block both manic and depressive第16页/共26页第十七页，共26

7、页。 Adverse effectsGI tract nausea, vomiting, diarrhea mental confusion, tremor, aphasia 失语症失语症, choreoathetosis 舞蹈舞蹈(wdo)症症, comaManagement of Li overdosage:peritoneal dialysis腹膜透析腹膜透析or hemodialysisiv NaCl第17页/共26页第十八页，共26页。第18页/共26页第十九页，共26页。depressant effect depression: mood elevation, spirit exc

8、itationThe onset of the mood-elevation is slow, 23 weeks第19页/共26页第二十页，共26页。第20页/共26页第二十一页，共26页。第21页/共26页第二十二页，共26页。pressure, arrhythmia, dry mouth, constipation第22页/共26页第二十三页，共26页。5-HT reuptake inhibitorfluoxetine 氟西汀氟西汀,百忧解百忧解u inhibit 5-HT reuptake selectively u treat depression: improve attention

9、 emotionu adverse effects: GI tract reaction, tremor u risk of life-threatening “serotonin-syndrome” co-administered with MAO inhibitors第23页/共26页第二十四页，共26页。 MAO inhibitor Phenelzine 苯乙肼苯乙肼 inhibit MAO nonselectively treat mild, moderate depression, also phobic states恐怖恐怖(kngb)状态状态 side effects: orthostatic hypotension, nausea, headache, insomnia