肿瘤转移英文版

1、3what is metastasis?repwnexthypothesis of tumor metastasiscancer stem cells肿瘤细胞非致橘性 motivate and maintain the growth of cancer cells potentiality plasticity make them easy to survivei nextinvasion（侵犯）intravasation （内？extravasation （夕卜俞仁涛cancer 川 yhis-hisjsinvasiona. 靠nmn可年拉尔1 就用j坐正i二打时他 r小j加7aim的l n

2、n tq. 1*11 .stable cell relativ牛genes, movable cell2 .protein expression3 .movement mechanismlamininlamininfibersfiberscollagencollagenfibronectinfibronectingrowth factorgrowth factorsintegrinintegrinfocaf adhesion complexesactin cytoskeletonsignalsnucleusprotein synthesisfachmentsoluble signalsgrow

3、th factor receptorsproliferation. differentiationmigration. shape changecytoskeleton-m ediated signalsgrowth factor receptorextracellular matrixintravasation1 .angiogenesis2.immune escapel-eucicct infenoothelia1l acttivatlormgiznlyl-l-tawiox-moriltiaicj cj tycop ro l&l nf-ft=biecrin comr- 1 4d)xe-hh

4、 心亡 tirisilyl-lwitfi x-modlfigcl 13 lycc protoin1。八。m oattra ut41号find。计thatrollingp-sscalegtin三l人nit(gmp- 1 40)acilvaiinq iiiqmco3-4e-.nlrotln ir：am-1(blami-1 (gmf- 3q)ssi alyl-l-qwik x-modiried y iy c o p rota j nl=alqohrifirmaoie0czrecam-1 (onai act i “用才 cctramsmion ationextravasationthe inverse

5、growthadhesion to 匕 ilserrie nt mem branepassage througk extracglllilar miitrixprocess of invasionadhesion to and invasion of basement membraneclonal expansion, growth, diversification. iiingioy gr-ticjsisrx/lotastcatic sutxclonci ntravciscili oni nff?rfiration with hostlympkoici c；ghotumor collembo

6、lusextrsvasationmetastaticdepositlangiogenesismalignant tumor metastasispathway恶性肿瘤常见的转移途径common metastasis pathway1. fymphatic metastasis淋巴道转移z hematogenous metastasis 血道转移3. implantation metastasis 种植 性转移nexttf年/三移,以上rf i 工* aifsisdjsojdui snouabojvuidii= apou lidnixi puoasq apou liciluai iuolboj

7、i9ss9a lfdlual 1/90 jqoueo：ssaoojddzlsdjsdjaiu 3卬叫 lung livermous metastasisnext|1 metastasis pathway(1) body veini lung(2) portal vein1 li ver(3) pulmonary veins total body ( brain , bone , kidney , adrenal glands ) next chest、 celiac pericardial cavityi metastasisnextbioremediation 生物low side effects用血液分图机采集一定jxi的外周血.在gmp实监室里.分湍单个 核细胞理于培养版中，加入培养液和细胞因子.刺淞细胞活化、出殖。wide rangeclear goal治疗有效杀灭 肿檎细胞.促 进病员康复* 改苦病员生活 质中.经7-21天细胞培养,细胞数增至原有效航的1o0o倍.先 疫泰伤徒力也加2q-100倍.生物治疗echanism of cell metastasis cell adhesion molecule(cam) deg