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( 2 - t a i l e d )I R C - S R CB a s e d o n p o s i t i v e r a n k s W i l c o x o n S i g n e d R a n k s T e s to to so 1) 2). 1) 2). to D R E V * S K L E V R E V C r o s s t a b u l a t i o . 0 %7 6 . 0 %1 0 0 . 0 %741071814 0 . 9 %5 9 . 1 %1 0 0 . 0 %1212563773 2 . 1 %6 7 . 9 %1 0 0 . 0 %C o u n t% wi t h i n P A M I D R E VC o u n t% wi t h i n P A M I D R E VC o u n t% wi t h i n P A M I D R E VP a m i d r o n a t eP l a c e b M I D R E VT o t a lY e L E V R E VT o t a lR i s k E s t i m a t e. 4 5 6. 2 9 3. 7 1 0. 5 8 7. 4 3 2. 7 9 51 . 2 8 61 . 1 1 31 . 4 8 6377O d d s R a t i o f o r P A M I D R E V( P a m i d r o n a t e / P l a c e b o )F o r c o h o r t S K L E V R E V =Y e sF o r c o h o r t S K L E V R E V =o f V a l i d C a s e sV a l u eL o w e rU p p e % C o n f i d e n c eI n t e r v a I P E S R E V * L I P C R E V C r o s s t a b u l a t i o . 5 %3 0 . 5 %1 0 0 . 0 %1983515493 6 . 1 %6 3 . 9 %1 0 0 . 0 %53750010375 1 . 8 %4 8 . 2 %1 0 0 . 0 %C o u n t% w i t h i n P I P E S R E VC o u n t% w i t h i n P I P E S R E VC o u n t% w i t h i n P I P E S R E VY e P E S R E VT o t a lY e P C R E VT o t a lR i s k E s t i m a t 0 3 33 . 1 1 15 . 2 2 91 . 9 2 61 . 6 9 82 . 1 8 5. 4 7 8. 4 1 2. 5 5 41037O d d s R a t i o f o P E S R E V ( Y e s / N o )F o r c o h o r t L I P C R E V =Y e sF o r c o h o r t L I P C R E V = N o f V a l i d C a s e sV a l u eL o w e rU p p e % C o n f i d e n c eI n t e r v a s to to so 1) 2). 1) 2). to R T R E V * D E A T H R E V C r o s s t a b u l a t i o . 0 %8 5 . 0 %1 0 0 . 0 %1619354 5 . 7 %5 4 . 3 %1 0 0 . 0 %2253752 9 . 3 %7 0 . 7 %1 0 0 . 0 %C o u n t% w i t h i n T R T R E VC o u n t% w i t h i n T R T R E VC o u n t% w i t h i n T R T R E VA n t i s e p t i cC o n t r o T R E VT o t a lD e a t hN o D e a t A T H R E VT o t a lC h i - S q u a r e T e s t 4 9 50 0 47 . 0 7 81. 0 0 88 . 6 8 71. 0 0 3. 0 0 5. 0 0 48 . 3 8 21. 0 0 475P e a r s o n C h i - S q u a r eC o n t i n u i t y C o r r e c t i o i k e l i h o o d R a t i oF i s h e r s E x a c t T e s tL i n e a r - b y - L i n e a rA s s o c i a t i o o f V a l i d C a s e sV a l u s y m p . S i g .( 2 - s i d e d )E x a c t S i g .( 2 - s i d e d )E x a c t S i g .( 1 - s i d e d )C o m p u t e d o n l y f o r a 2 x 2 t a b l 0 c e l l s ( . 0 % ) h a v e e x p e c t e d c o u n t l e s s t h a n 5 . T h e m i n i m u m e x p e c t e d c o u n t i . 2 7 s to to so 1) 2). 1) 2). to E L F R E V * S U R G R E V C r o s s t a b u l a t i o . 8 %1 7 . 0 %5 8 . 8 %563683 . 0 %3 8 . 2 %4 1 . 2 %74911654 4 . 8 %5 5 . 2 %1 0 0 . 0 %C o u n t% o f T o t a lC o u n t% o f T o t a lC o u n t% o f T o t a lP r e s e n tA b s e n L F R E VT o t a lP r e s e n tA b s e n R G R E VT o t a lC h i - S q u a r e T e s t s. 0 0 0c N e m a r T e s o f V a l i d C a s e sV a l u eE x a c t S i g .( 2 - s i d e d )B i n o m i a l d i s t r i b u t i o n u s e d to to so 1) 2). 1) 2). to M O K E R E V * D E A T H R E V * A G E C r o s s t a b u l a t i o nC o u n mo k eN o S mo k O K E R E VT o t a lS mo k eN o S mo k O K E R E VT o t a lS mo k eN o S mo k O K E R E VT o t a lS mo k eN o S mo k O K E R E VT o t a - 5 45 5 - 5 96 0 - 6 46 5 - 6 9D e a t hN o D e a t A T H R E VT o t a lM a n t e l - H a e n s z e l C o m m o n O d d s R a t i o E s t i m a t 4 5 7. 3 7 7. 0 3 1. 0 0 01 . 3 7 21 . 5 4 8. 3 1 6. 4 3 7E s t i m a t el n ( E s t i m a t e )S t d . E r r o r o f l n ( E s t i m a t e )As y m p . S i g . ( 2 - s i d e d )L o w e r B o u n dU p p e r B o u n dC o m m o n O d d sR a t i oL o w e r B o u n dU p p e r B o u n dl n ( C o m m o nO d d s R a t i o )As y m p . 9 5 % C o n f i d e n c eI n t e r v a lT h e M a n t e l - H a e n s z e l c o m m o n o d d s r a t i o e s t i m a t e i s a s y m p t o t i c a l l y n o r m a l l yd i s t r i b u t e d u n d e r t h e c o m m o n o d d s r a t i o o f 1 . 0 0 0 a s s u m p t i o n . S o i s t h e n a t u r a l l o g o ft h e e s t i m a t e to in of A of is if 3 in A R I T A L * C A N C R E V C r o s s t a b u l a t i o . 13 7 . 97 6 . 03 8 . 2 %6 1 . 8 %1 0 0 . 0 %- 2 . 32 . 31161082241 1 2 . 31 1 1 . 72 2 4 . 05 1 . 8 %4 8 . 2 %1 0 0 . 0 % 767561236 1 . 66 1 . 41 2 3 . 05 4 . 5 %4 5 . 5 %1 0 0 . 0 %1 . 1- 1 . 155105 . 05 . 01 0 . 05 0 . 0 %5 0 . 0 %1 0 0 . 0 %2172164332 1 7 . 02 1 6 . 04 3 3 . 05 0 . 1 %4 9 . 9 %1 0 0 . 0 %C o u n tE x p e c t e d C o u n t% w i t h i n M A R I T A LA d j u s t e d R e s i d u a lC o u n tE x p e c t e d C o u n t% w i t h i n M A R I T A LA d j u s t e d R e s i d u a lC o u n tE x p e c t e d C o u n t% w i t h i n M A R I T A LA d j u s t e d R e s i d u a lC o u n tE x p e c t e d C o u n t% w i t h i n M A R I T A LA d j u s t e d R e s i d u a lC o u n tE x p e c t e d C o u n t% w i t h i n M A R I T A LS i n g l eM a r r i e dW i d o w e dD i v / S e R I T A LT o t a lC a n c e rN o C a n c e N C R E VT o t a lC h i - S q u a r e T e s t 5 3 01 3 75 . 5 7 23. 1 3 43 . 6 3 11. 0 5 74 3 3P e a r s o n C h i - S q u a r eL i k e l i h o o d R a t i oL i n e a r - b y - L i n e a rA s s o c i a t i o o f V a l i d C a s e sV a l u s y m p . S i g .( 2 - s i d e d )1 c e l l s ( 1 2 . 5 % ) h a e xp e c t e d c o u n t l e s s t h a n 5 . T h em i n i m u m e xp e c t e d c o u n t i s 4 . 9 9 s g / s to 0 - O S E * E X H S T N C r o s s t a b u l a t i o nC o u n 1816 21813 41714 4185912711234D O S ET o t a H S T NT o t a lS y m m e t r i c M e a s u r e s. 1 2 4. 1 0 41 . 1 6 6. 2 4 3. 2 6 9. 2 2 01 . 1 6 6. 2 4 371K e n d a l l s t a u - bG a m m aO r d in a l b yO r d in a o f V a l C a s e sV a l u eA s y m p .S t d . E r r o p p r o x . p p r o x . S N o t a s s u m in g t h e n u l l h y p o t h e s a . U s in g t h e a s y m p t o t s t a n d a r d e r r o r a s s u m in g t h e n u l l h y p o t h e s b . to k of of a n k 5 . 6 51812 6 1 . 1 51792 6 6 . 1 4541D E L I V E R o t a T C O M e a n R a n kT e s t S t a t i s t i c 7 5 52. 2 5 2C h i - S q u a r s y m p . S i g T C O M EK r u s k a l W a l l i s T e s G r o u p i n g V a r i a b l e : D E L R 1973), p. 140. s k to to in I S K E L * E B E R T C r o s s t a b u l a t i o 13451 5 . 0 %5 . 0 %8 . 1 %2 8 . 1 %81311325 . 0 %8 . 1 %6 . 9 %2 0 . 0 %10 964836 . 3 %5 . 6 %4 0 . 0 %5 1 . 9 %4230881 6 02 6 . 3 %1 8 . 8 %5 5 . 0 %1 0 0 . 0 %C o u n t% o f T o t a lC o u n t% o f T o t a lC o u n t% o f T o t a lC o u n t% o f T o t a S K E LT o t a E R TT o t a lS y m m e t r i c M e a s u r e s. 3 8 9. 0 6 06 . 7 3 1. 0 0 0160K a p p aM e a s u r e o f A g r e e m e n o f V a l i d C a s e sV a l u eA s y m p .S t d . E r r o p p r o x . p p r o x . S i g .N o t a s s u m i n g t h e n u l l h y p o t h e s i s U s i n g t h e a s y m p t o t i c s t a n d a r d e r r o r a s s u m i n g t h e n u l l h y p o t h e s i s 1 to on on To - N O V 7 4 . 6 0 023 5 3 7 . 3 0 08 . 9 0 1. 0 0 01 0 6 1 0 8 . 02673 9 7 . 4 0 81 1 3 1 8 2 . 6269B e t w e e n G r o u p sW i t h i n G r o u p sT o t a lS u m o fS q u a r e e a n S q u a r i g .M u l t i p l e C o m p a r i s o n sD e p e n d e n t V a ri a b l e : C D 47 . 1 0 0 0 0 *2 . 9 7 1 7 4 9. 0 4 6. 0 9 6 0 11 4 . 1 0 3 9 91 2 . 5 0 0 0 0 *2 . 9 7 1 7 4 9. 0 0 05 . 4 9 6 0 11 9 . 5 0 3 9 9- 7 . 1 0 0 0 0 *2 . 9 7 1 7 4 9. 0 4 6- 1 4 . 1 0 3 9 9- . 0 9 6 0 15 . 4 0 0 0 02 . 9 7 1 7 4 9. 1 6 6- 1 . 6 0 3 9 91 2 . 4 0 3 9 9- 1 2 . 5 0 0 0 0 *2 . 9 7 1 7 4 9. 0 0 0- 1 9 . 5 0 3 9 9- 5 . 4 9 6 0 1- 5 . 4 0 0 0 02 . 9 7 1 7 4 9. 1 6 6- 1 2 . 4 0 3 9 91 . 6 0 3 9 97 . 1 0 0 0 02 . 9 7 1 7 4 9. 0 5 3- . 0 5 9 4 21 4 . 2 5 9 4 21 2 . 5 0 0 0 0 *2 . 9 7 1 7 4 9. 0 0 05 . 3 4 0 5 81 9 . 6 5 9 4 2- 7 . 1 0 0 0 02 . 9 7 1 7 4 9. 0 5 3- 1 4 . 2 5 9 4 2. 0 5 9 4 25 . 4 0 0 0 02 . 9 7 1 7 4 9. 2 1 1- 1 . 7 5 9 4 21 2 . 5 5 9 4 2- 1 2 . 5 0 0 0 0 *2 . 9 7 1 7 4 9. 0 0 0- 1 9 . 6 5 9 4 2- 5 . 3 4 0 5 8- 5 . 4 0 0 0 02 . 9 7 1 7 4 9. 2 1 1- 1 2 . 5 5 9 4 21 . 7 5 9 4 2( J ) T R I ) T u k e y B o n f e r r o n iM e a nD i f f e r e n c e( I - J )S t d . 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