Taurodeoxycholic-acid-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemETaurodeoxycholicacid(Standard)Cat.No.:HY-B1899RCASNo.:516-50-7分⼦式:C₂₆H₄₅NO₆S分⼦量:499.7作⽤靶点:EndogenousMetabolite;Gprotein-coupledBileAcidReceptor1;PARP;Apoptosis;NF-κB;PKA作⽤通路:MetabolicEnzyme/Protease;GPCR/GProtein;CellCycle/DNA

Damage;Epigenetics;Apoptosis;NF-κB;StemCell/Wnt;TGF-

beta/Smad储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Taurodeoxycholicacid(Standard)Taurodeoxycholicacid的分析标准品。本产品⽤于研究及分析应⽤。Taurodeoxycholatesodiumsalt⼀种胆盐相关的离⼦洗涤剂。Taurodeoxycholicacid在肝脏中将脱氧胆酸与Taurine(HY-B0351)偶联形成的。Taurodeoxycholicacid可⽤于分离膜蛋⽩，包括线粒体内膜蛋⽩。Taurodeoxycholicacid(TDCA)具有抗炎和REFERENCES[1].Villavicencio-QueijeiroA,etal.Thefully-activeandstructurally-stableformofthemitochondrialATPsynthaseofPolytomellasp.isdimeric.JBioenergBiomembr.2009Feb;41(1):1-13.[2].KispalG,etal.Isolationandcharacterizationof3-hydroxyacylcoenzymeAdehydrogenase-bindingproteinfrompigheartinnermitochondrialmembrane.JBiolChem.1986Oct25;261(30):14209-13.[3].ChoiHJ,etal.EvaluationofacuteandsubacutetoxicityofsodiumTaurodeoxycholateinrats.DrugChemToxicol.2021May;44(3):268-276.[4].SatoH,etal.NovelpotentandselectivebileacidderivativesasTGR5agonists:biologicalscreening,structure-activityrelationships,andmolecularmodelingstudies.JMedChem.2008Mar27;51(6):1831-41.[5].GertzenCG,etal.MutationalmappingofthetransmembranebindingsiteoftheG-proteincoupledreceptorTGR5andbindingmodepredictionofTGR5agonists.EurJMedChem.2015Nov2;104:57-72.[6].BenzC,etal.Effectoftauroursodeoxycholicacidonbileacid-inducedapoptosisinprimaryhumanhepatocytes.EurJClinInvest.2000Mar;30(3):203-9.[7].XieQ,etal.Effectoftauroursodeoxycholicacidonendoplasmicreticulumstress-inducedcaspase-12activation.Hepatology.2002Sep;36(3):592-601.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[8].YamaguchiJ,etal.Taurodeoxycholateincreasesintestinalepithelialcellproliferationthroughc-mycexpression.Surgery.2004Feb;135(2):215-21.[9].ZouY,etal.TaurodeoxycholateamelioratesDSS-inducedcolitisinmice.IntImmunopharmacol.2023Sep;122:110628.[10].KeeneCD,etal.Abileacidprotectsagainstmotorandcognitivedeficitsandreducesstriataldegenerationinthe3-nitropropionicacidmodelofHuntington'sdisease.ExpNeurol.2001Oct;171(2):351-60.[11].KeeneCD,etal.Tauroursodeoxycholicacid,abileacid,isneuroprotectiveinatransgenicanimalmodelofHuntington'sdisease.ProcNatlAcadSciUSA.2002Aug6;99(16):10671-6.[12].ChangS,etal.TaurodeoxycholateIncreasestheNumberofMyeloid-DerivedSuppressorCellsThatAmeliorateSepsisinMice.FrontImmunol.2018Sep18;9:1984.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformed