Triptolide-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemETriptolide(Standard)Cat.No.:HY-32735RCASNo.:38748-32-2分子式:C₂₀H₂₄O₆分子量:360.4作用靶点:NF-κB;NF-κB;Apoptosis;Apoptosis作用通路:NF-κB;Apoptosis储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Triptolide(Standard)是Triptolide的分析标准品。本产品用于研究及分析应用。Triptolide是从雷公藤根中提取的二萜类三环氧化物，具有免疫抑制，抗炎，抗增殖和抗肿瘤作用。雷公藤内酯是NF-κB活化的抑制剂[1][2][3][4][5][6]。IC50&Targetheatshockfactor(HSF1)[1]IC50:47to73nM(MDM2,inALLcelllines)[2]REFERENCESGangulyS,etal.TargetingHSF1disruptsHSP90chaperonefunctioninchroniclymphocyticleukemia.Oncotarget.2015Oct13;6(31):31767-79.HuangM,etal.TriptolideinhibitsMDM2andinducesapoptosisinacutelymphoblasticleukemiacellsthroughap53-independentpathway.MolCancerTher.2013Feb;12(2):184-94.XuP,etal.TriptolideInhibitedCytotoxicityofDifferentiatedPC12CellsInducedbyAmyloid-Beta25-35viatheAutophagyPathway.PLoSOne.2015Nov10;10(11):e0142719.KongLL,etal.InhibitionofP-glycoproteinGeneExpressionandFunctionEnhancesTriptolide-inducedHepatotoxicityinMice.SciRep.2015Jul2;5:11747.ZhangW,etal.TriptolideCombinedwithRadiotherapyfortheTreatmentofNasopharyngealCarcinomaviaNF-κB-RelatedMechanism.IntJMolSci.2016Dec19;17(12).pii:E2139.CaiJ,etal.NaturalproducttriptolideinducesGSDME-mediatedpyroptosisinheadandneckcancerthroughsuppressingmitochondrialhexokinase-ΙΙ.JExpClinCancerRes.2021;40(1):190.Published2021Jun9.GangulyS,etal.TargetingHSF1disruptsHSP90chaperonefunctioninchroniclymphocyticleukemia.Oncotarget.2015Oct13;6(31):31767-79.1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEHuangM,etal.TriptolideinhibitsMDM2andinducesapoptosisinacutelymphoblasticleukemiacellsthroughap53-independentpathway.MolCancerTher.2013Feb;12(2):184-94.XuP,etal.TriptolideInhibitedCytotoxicityofDifferentiatedPC12CellsInducedbyAmyloid-Beta25-35viatheAutophagyPathway.PLoSOne.2015Nov10;10(11):e0142719.KongLL,etal.InhibitionofP-glycoproteinGeneExpressionandFunctionEnhancesTriptolide-inducedHepatotoxicityinMice.SciRep.2015Jul2;5:11747.ZhangW,etal.TriptolideCombinedwithRadiotherapyfortheTreatmentofNasopharyngealCarcinomaviaNF-κB-RelatedMechanism.IntJMolSci.2016Dec19;17(12).pii:E2139.CaiJ,etal.NaturalproducttriptolideinducesGSDME-mediatedpyroptosisinheadandneckcancerthroughsuppressingmitochondrialhexokinase-ΙΙ.JExpClinCancerRes.2021;40(1):190.Published2021Jun9.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplica