Propiomazine-hydrochloride-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEPropiomazinehydrochlorideCat.No.:HY-U00051ACASNo.:1240-15-9分子式:C₂₀H₂₅ClN₂OS分子量:376.94作用靶点:HistamineReceptor作用通路:GPCR/GProtein;Immunology/Inflammation;NeuronalSignaling储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Propiomazinehydrochloride是一种具有口服活性的抗组胺剂，具有镇静作用。Propiomazinehydrochloride可用于失眠相关的研究。体内研究Propiomazine(0.2mg/kg,nasaladministration,rats)hydrochlorideisquicklyabsorbed,followedbyrapidreductionoftheplasmaconcentrations[3].Propiomazine(25mg/kg,i.p.,at0and3hafterchallenge)hydrochlorideprotectsratsagainstCCl4-inducedhepaticinjury[4].Propiomazine(0.31-20mg/kg,i.v.)hydrochlorideincreasesplasmaprolactinconcentrationsinrats[5].REFERENCESBMidgren,etal.Effectsofsingledosesofpropiomazine,aphenothiazinehypnotic,onsleepandoxygenationinpatientswithstablechronicobstructivepulmonarydisease.Respiration.1990;57(4):239-42.ThunanderSundbomL,etal.Sedatingantihistamines-riskofsevereintoxication.Lakartidningen.2021Sep30;118:21037.C.Bjerre,etal.Bioavailabilityofthesedativepropiomazineafternasaladministrationinrats.InternationalJournalofPharmaceutics,1996,144(2),217-224.FTSerratoni,etal.Promethazineprotectionincarbontetrachlorideliverinjury.Anelectronmicroscopicstudy.ArchPathol.1969Jan;87(1):46-51.FayezM,etal.Effectofpropiomazineonplasmaprolactinintherat:counteractionbyL-dopa.ProcSocExpBiolMed.1985Apr;178(4):606-9.McePdfHeight1/1 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021