Piroxicam-olamine-CP-16171-olamine-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEPiroxicamolamineCat.No.:HY-B0253ACASNo.:85056-47-9Synonyms:CP-16171olamine分子式:C₁₇H₂₀N₄O₅S分子量:392.43作用靶点:COX作用通路:Immunology/Inflammation储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Piroxicamolamine(CP-16171)是一种非甾体抗炎剂，能够抑制COX的活性，对人单核细胞COX-1和COX-2的IC50值分别为47和25μM。IC50&TargetIC50:47μM(COX-1,inhumanmonocytes),25μM(COX-2,humanmonocytes)[1]体外研究Piroxicam(CP-16171)isanon-steroidalanti-inflammatorydrugs,actsasaCOXinhibitor,withIC50sof47,25μMforhumanmonocyteCOX-1andCOX-2,respectively[1].Piroxicam(CP-16171)(167,333,500μM)decreasescellpopulationofT24andthe5637cells.Piroxicam(CP-16171)(500μM)alsoreducesthecellviabilityofT24and5637cell,andissignificantlyeffectivewhencombinedwith0.05μMcarboplatin.ThecombinationalsoinhibitsKi-67expressioninboothcells[3].体内研究Piroxicam(CP-16171)(0.3mg/kgqd24-hp.o.)reducestumorvolumein12of18dogs,andsuchandeffectisviainductionofapoptosisandreductioninurinebasicfibroblastgrowthfactorconcentration[2].客户使用本产品发表的科研文献• Chem-BiolInteract.2021,109425.Seemorecustomervalidationsonwww.MedChemEREFERENCES1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEKatoM,etal.Cyclooxygenase-1andcyclooxygenase-2selectivityofnon-steroidalanti-inflammatorydrugs:investigationusinghumanperipheralmonocytes.JPharmPharmacol.2001Dec;53(12):1679-85.MohammedSI,etal.Effectsofthecyclooxygenaseinhibitor,piroxicam,ontumorresponse,apoptosis,andangiogenesisinacaninemodelofhumaninvasiveurinarybladdercancer.CancerRes.2002Jan15;62(2):356-8.SilvaJ,etal.SynergisticEffectofCarboplatinandPiroxicamonTwoBladderCancerCellLines.AnticancerRes.2017Apr;37(4):1737-1745.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-