Rhoifolin-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemERhoifolin(Standard)Cat.No.:HY-N0755RCASNo.:17306-46-6分⼦式:C₂₇H₃₀O₁₄分⼦量:578.52作⽤靶点:InsulinReceptor;GLUT;NF-κB;p38MAPK;Autophagy作⽤通路:ProteinTyrosineKinase/RTK;MembraneTransporter/IonChannel;NF-κB;MAPK/ERKPathway;Autophagy储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Rhoifolin(Standard)Rhoifolin的分析标准品。本产品⽤于研究及分析应⽤。Rhoifolin⼀种酮糖苷，可从野洋漆分离。Rhoifolin通过增强脂联素分泌、胰岛素受体-β(insulinreceptor-β)的酪氨酸磷酸化和GLUT4易位来发挥抗糖尿病作⽤。Rhoifolin通过对炎症介质的多层次调控发挥抗炎作⽤。Rhoifolin通过RANKL诱导的NF-κB和MAPK途径改钛颗粒刺激的⾻溶解并减弱破⾻细胞⽣成。Rhoifolin对多种癌细胞系也具有细胞毒性活性。REFERENCES[1].RaoYK,etal.Insulin-MimeticActionofRhoifolinandCosmosiinIsolatedfromCitrusgrandis(L.)OsbeckLeaves:EnhancedAdiponectinSecretionandInsulinReceptorPhosphorylationin3T3-L1Cells.EvidBasedComplementAlternatMed.2011;2011:624375.[2].LiaoS,etal.Rhoifolinamelioratestitaniumparticle-stimulatedosteolysisandattenuatesosteoclastogenesisviaRANKL-inducedNF-κBandMAPKpathways.JCellPhysiol.2019Aug;234(10):17600-17611.[3].Eldahshan.O.A,etal.Rhoifolin;APotentAntiproliferativeEffectonCancerCellLines.JournalofPharmaceuticalResearchInternational,2012,3(1),pp.46-53.[4].OmamaE.El-Shawi,etal.ProtectiveEffectofRhoifolinonGammaIrradiationInducedCardiacDysfunctionsinAlbinoMice.Feb15,2014.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>