Novobiocin-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemENovobiocin(Standard)Cat.No.:HY-B0425RCASNo.:303-81-1分⼦式:C₃₁H₃₆N₂O₁₁分⼦量:612.62作⽤靶点:Antibiotic;DNA/RNASynthesis;HSP;Apoptosis;Bacterial;Orthopoxvirus作⽤通路:Anti-infection;CellCycle/DNADamage;MetabolicEnzyme/Protease;Apoptosis储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Novobiocin(Standard)Novobiocin的分析标准品。本产品⽤于研究及分析应⽤。Novobiocin(Albamycin)还DNA促旋酶抑制剂和热休克蛋⽩90(Hsp90)拮抗剂。Novobiocin具有研究⾼度耐药性肺炎球感染的潜⼒.Novobiocin具有抗正痘活性[1][2][3][4]。REFERENCES[1].MarcuMG,etal.Theheatshockprotein90antagonistnovobiocininteractswithapreviouslyunrecognizedATP-bindingdomaininthecarboxylterminusofthechaperone.JBiolChem.2000Nov24;275(47):37181-6.[2].Ali-OsmanF,etal.TopoisomeraseIIinhibitionandalteredkineticsofformationandrepairofnitrosoureaandcisplatin-inducedDNAinterstrandcross-linksandcytotoxicityinhumanglioblastomacells.CancerRes.1993Dec1;53(23):5663-8.[3].Rodríguez-CerratoV,etal.Comparativeefficacyofnovobiocinandamoxicillininexperimentalsepsiscausedbybeta-lactam-susceptibleandhighlyresistantpneumococci.IntJAntimicrobAgents.2010Jun;35(6):544-9.[4].EderJP,etal.AphaseIclinicaltrialofnovobiocin,amodulatorofalkylatingagentcytotoxicity.CancerRes.1991Jan15;51(2):510-3.[5].BhatiaS,etal.TargetingHSP90dimerizationviatheCterminusiseffectiveinimatinib-resistantCMLandlackstheheatshockresponse.Blood.2018Jul19;132(3):307-320.[6].SmeeDF.Progressinthediscoveryofcompoundsinhibitingorthopoxvirusesinanimalmodels.AntivirChemChemother.2008;19(3):115-24.[7].SmeeDF.Progressinthediscoveryofcompoundsinhibitingorthopoxvirusesinanimalmodels.AntivirChemChemother.2008;19(3):115-24.McePdfHeight1/1MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400