Novobiocin-sodium-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemENovobiocinsodium(Standard)Cat.No.:HY-B0425ARCASNo.:1476-53-5分⼦式:C₃₁H₃₅N₂NaO₁₁分⼦量:634.61作⽤靶点:Bacterial;Antibiotic;Orthopoxvirus;Apoptosis;DNA/RNASynthesis;HSP作⽤通路:Anti-infection;Apoptosis;CellCycle/DNADamage;MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Novobiocin(sodium)(Standard)Novobiocin(sodium)的分析标准品。本产品⽤于研究及分析应⽤。Novobiocin(Albamycin)sodium⼀种有效且具有⼝服活性的抗⽣素。Novobiocinsodium还DNA促旋酶抑制剂和热休克蛋⽩90(Hsp90)拮抗剂。Novobiocinsodium具有研究⾼度耐药性肺炎球感染的潜⼒。NovobiocinSodium具有抗正痘病毒活性[1][2][3][4]。IC50&TargetIC50:700μM(HSP90)[2]REFERENCES[1].BhatiaS,etal.TargetingHSP90dimerizationviatheCterminusiseffectiveinimatinib-resistantCMLandlackstheheatshockresponse.Blood.2018Jul19;132(3):307-320.[2].MarcuMG,etal.Theheatshockprotein90antagonistnovobiocininteractswithapreviouslyunrecognizedATP-bindingdomaininthecarboxylterminusofthechaperone.JBiolChem.2000Nov24;275(47):37181-6.[3].Ali-OsmanF,etal.TopoisomeraseIIinhibitionandalteredkineticsofformationandrepairofnitrosoureaandcisplatin-inducedDNAinterstrandcross-linksandcytotoxicityinhumanglioblastomacells.CancerRes.1993Dec1;53(23):5663-8.[4].Rodríguez-CerratoV,etal.Comparativeefficacyofnovobiocinandamoxicillininexperimentalsepsiscausedbybeta-lactam-susceptibleandhighlyresistantpneumococci.IntJAntimicrobAgents.2010Jun;35(6):544-9.[5].EderJP,etal.AphaseIclinicaltrialofnovobiocin,amodulatorofalkylatingagentcytotoxicity.CancerRes.1991Jan15;51(2):510-3.[6].SmeeDF.Progressinthediscoveryofcompoundsinhibitingorthopoxvirusesinanimalmodels.AntivirChemChemother.2008;19(3):115-24.McePdfHeight1/1MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-