Dantrolene-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEDantrolene(Standard)Cat.No.:HY-12542RCASNo.:7261-97-4分⼦式:C₁₄H₁₀N₄O₅分⼦量:314.25作⽤靶点:CalciumChannel;Autophagy作⽤通路:MembraneTransporter/IonChannel;NeuronalSignaling;Autophagy储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Dantrolene(Standard)Dantrolene的分析标准品。本产品⽤于研究及分析应⽤。Dantrolene⼀种具有⼝服活性的、⾮竞争性⾕胱⽢肽还原酶抑制剂，Ki为111.6μM，IC50为52.3μM。Dantrolene⼀种兰尼定受体(RyR)拮抗剂和Ca2+信号稳定剂。Dantrolene⼀种直接作⽤的⾻骼肌松弛剂。Dantrolene可⽤于肌⾁痉挛、恶性⾼热、亨廷顿病和其他抗精神病药恶性综合征的研究。REFERENCES[1].FZhao,etal.DantroleneinhibitionofryanodinereceptorCa2+releasechannels.Molecularmechanismandisoformselectivity.JBiolChem.2001Apr27;276(17):13810-6.[2].XiChen,etal.DantroleneisneuroprotectiveinHuntington'sdiseasetransgenicmousemodel.MolNeurodegener.2011Nov25;6:81.[3].ChristopherBSylvester,etal.Dantroleneinhibitslysophosphatidylcholine-inducedvalveinterstitialcellcalcificnoduleformationviablockadeoftheryanodinereceptor.FrontCardiovascMed.2023Mar30:10:1112965.[4].BenjaminLiou,etal.ModulatingryanodinereceptorswithdantroleneattenuatesneuronopathicphenotypeinGaucherdiseasemice.HumMolGenet.2016Dec1;25(23):5126-5141.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021