Cyclobenzaprine-d3-1-hydrochloride-MK130-d-sub-3-sub-1-hydrochloride-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemECyclobenzaprine-d3-1hydrochlorideCat.No.:HY-B0740S3CASNo.:2712897-38-4Synonyms:MK130-d3-1hydrochloride分⼦式:C₂₀H₁₉D₃ClN分⼦量:314.87作⽤靶点:Isotope-LabeledCompounds;5-HTReceptor;Parasite作⽤通路:Others;GPCR/GProtein;NeuronalSignaling;Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Cyclobenzaprine-d3-1hydrochloride(MK130-d3-1hydrochloride)氚代标记的Cyclobenzaprinehydrochloride(HY-B0740)。Cyclobenzaprine(MK130)hydrochloride⼀种⼝服有效的5-HT2receptor拮抗剂。Cyclobenzaprinehydrochloride作⽤于中枢神经系统，可使⾻骼肌松弛，缓解肌⾁痉挛并减少疼痛。此外Cyclobenzaprinehydrochloride还具有抗原⾍活性。Cyclobenzaprinehydrochloride有望⽤于急性、疼痛⾻骼肌疾病及感染疾病领域研究[1][2][3][4][5]。REFERENCES[1].Kobayashi,H.,Y.Hasegawa,andH.Ono,Cyclobenzaprine,acentrallyactingmusclerelaxant,actsondescendingserotonergicsystems.EurJPharmacol,1996.311(1):p.29-35.[2].BorensteinDG&KornS.Efficacyofalow-doseregimenofcyclobenzaprinehydrochlorideinacuteskeletalmusclespasm:resultsoftwoplacebo-controlledtrials[J].Clinicaltherapeutics,2003,25(4):1056-1073.[3].ShareNN,etal.Cyclobenzaprine:anovelcentrallyactingskeletalmusclerelaxant[J].Neuropharmacology,1975,14(9):675-684.[4].Honda,M.,T.Nishida,andH.Ono,Tricyclicanalogscyclobenzaprine,amitriptylineandcyproheptadineinhibitthespinalreflextransmissionthrough5-HT(2)receptors.EurJPharmacol,2003.458(1-2):p.91-9.[5].Cunha-JúniorEF,etal.CyclobenzaprineRaisesROSLevelsinLeishmaniainfantumandReducesParasiteBurdeninInfectedMice.PLoSNeglTropDis.2017Jan3;11(1):e0005281.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;