3-5-6-7-8-3-4-Heptemthoxyflavone-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE3,5,6,7,8,3',4'-Heptemthoxyflavone(Standard)Cat.No.:HY-N2038RCASNo.:1178-24-1分⼦式:C₂₂H₂₄O₉分⼦量:432.42作⽤靶点:Phosphodiesterase(PDE)作⽤通路:MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性3,?5,?6,?7,?8,?3',?4'-Heptemthoxyflavone(Standard)3,?5,?6,?7,?8,?3',?4'-Heptemthoxyflavone的分析标准品。本产品⽤于研究及分析应⽤。3,5,6,7,8,3',4'-Heptemthoxyflavone⼀种蜜柑⽪中的酮，⼝服有效的CREB激活剂，具有抗肿瘤和抗神经炎症活性。3,5,6,7,8,3',4'-Heptemthoxyflavone能抑制胶原酶的活性，增加⼈真⽪成纤维细胞新⽣(HDFn)细胞中I型前胶原的含量。3,5,6,7,8,3',4'-Heptemthoxyflavone通过cAMP/ERK/CREB信号通路，诱导脑性神经营养因⼦(BDNF)表达，降低C6胶质瘤中磷酸⼆酯酶活性。REFERENCES[1].KimHI,etal.3,5,6,7,8,3',4'-Heptamethoxyflavone,aCitrusFlavonoid,InhibitsCollagenaseActivityandInducesTypeIProcollagenSynthesisinHDFnCells.IntJMolSci.2018Feb22;19(2).[2].IwaseY,etal.Cancerchemopreventiveactivityof3,5,6,7,8,3',4'-heptamethoxyflavonefromthepeelofcitrusplants.CancerLett.2001Feb10;163(1):7-9.[3].Adhikari-DevkotaA,etal.Anti-neuroinflammatoryactivitiesofextractandpolymethoxyflavonoidsfromimmaturefruitpeelsofCitrus'Hebesu'.JFoodBiochem.2019Jun;43(6):e12813.[4].SawamotoA,etal.Citrusflavonoid3,5,6,7,8,3',4'-heptamethoxyflavoneinducesBDNFviacAMP/ERK/CREBsignalingandreducesphosphodiesteraseactivityinC6cells.PharmacolRep.2019Aug;71(4):653-658.[5].SawamotoA,etal.3,5,6,7,8,3',4'-HeptamethoxyflavoneAmelioratesDepressive-LikeBehaviorandHippocampalNeurochemicalChangesinChronicUnpredictableMildStressedMicebyRegulatingtheBrain-DerivedNeurotrophicFactor:RequirementforERKActivation.IntJMolSci.2017Oct12;18(10):2133.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792